Evidence map›Paper›PMID 27758862›Full record

ArticleThe Journal of biological chemistry2017

Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE.

Gargi Mahapatra, Ashwathy Varughese, Qinqin Ji, Icksoo Lee, Jenney Liu, Asmita Vaishnav, Christopher Sinkler, Alexandr A Kapralov, Carlos T Moraes, Thomas H Sanderson and 7 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. CytochromeSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. The essential role of adenine nucleotide translocase 4 on male reproductive function in mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. De novo sequencing and construction of a unique antibody for the recognition of alternative conformations of cytochromeProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Mitochondrial Management of Reactive Oxygen Species.Antioxidants (Basel, Switzerland) · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Gargi MahapatraFrom the Center for Molecular Medicine and Genetics and.
Ashwathy VarugheseFrom the Center for Molecular Medicine and Genetics and.
Qinqin Jithe Chemistry Department and.
Icksoo LeeFrom the Center for Molecular Medicine and Genetics and.
Jenney LiuFrom the Center for Molecular Medicine and Genetics and.
Asmita Vaishnavthe Departments of Biochemistry and Molecular Biology.
Christopher SinklerFrom the Center for Molecular Medicine and Genetics and.
Alexandr A Kapralovthe Center for Free Radical and Antioxidant Health and the Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.
Carlos T Moraesthe Department of Neurology, University of Miami School of Medicine, Miami, Florida 33136, and.
Thomas H SandersonEmergency Medicine, and.
Timothy L StemmlerPharmaceutical Sciences, Wayne State University, Detroit, Michigan 48201.
Lawrence I GrossmanFrom the Center for Molecular Medicine and Genetics and.
Valerian E Kaganthe Center for Free Radical and Antioxidant Health and the Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219.
Joseph S Brunzellethe Life Sciences Collaborative Access Team, Northwestern University, Center for Synchrotron Research, Argonne, Illinois 60439.
Arthur R Salomonthe MCB Department, Brown University, Providence, Rhode Island 02912.
Brian F P Edwardsthe Departments of Biochemistry and Molecular Biology.
Maik HüttemannFrom the Center for Molecular Medicine and Genetics and mhuttema@med.wayne.edu.
Wayne State University · USBrown University · USUniversity of Pittsburgh · USDankook University · KRNorthwestern University · USUniversity of Miami · US

Funding

Structural Insights into the Function of FrataxinR01DK068139 · NIDDK · WAYNE STATE UNIVERSITY · PI STEMMLER, TIMOTHY LOUIS · 2005 to 2015
$3.5M
Detroit Cardiovascular Training ProgramT32HL120822 · NHLBI · WAYNE STATE UNIVERSITY · PI LEVY, PHILLIP DAVID · 2014 to 2023
$1.8M
Regulation of Respiration and Apoptosis by Cytochrome c Phosphorylation.R01GM089900 · NIGMS · WAYNE STATE UNIVERSITY · PI HUETTEMANN, MAIK · 2010 to 2014
$1.4M
Limiting brain reperfusion injury by controlling mitochondrial functionR01NS091242 · NINDS · WAYNE STATE UNIVERSITY · PI HUETTEMANN, MAIK, SANDERSON, THOMAS HUDSON · 2015 to 2018
$1.3M
NHLBI NIH HHS T32 HL120822NIDDK NIH HHS R01 DK068139NIGMS NIH HHS R01 GM089900NINDS NIH HHS R01 NS091242
6 · The paper itself

Abstract

Mammalian cytochrome c (Cytc) plays a key role in cellular life and death decisions, functioning as an electron carrier in the electron transport chain and as a trigger of apoptosis when released from the mitochondria. However, its regulation is not well understood. We show that the major fraction of Cytc isolated from kidneys is phosphorylated on Thr

Indexed as

Adenylate KinaseAnimalsApoptosisCell RespirationCrystallography, X-RayCytochromes cElectron TransportElectron Transport Complex IVKidneyMembrane Potential, MitochondrialMiceMitochondriaOxidation-ReductionPhosphorylationProtein ConformationReactive Oxygen SpeciesAdenylate KinaseCytochromes cElectron Transport Complex IVReactive Oxygen SpeciesThreonineAMP-activated kinase (AMPK)apoptosiscell signalingcytochrome celectron transport chainelectron transport system (ETS)kidney metabolismmitochondriaoxidative phosphorylationrespiration

Identifiers

PMID27758862
PMCPMC5217700
OpenAlexW2528064348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.