GuidelineHaematologica2017
Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome.
Guideline in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Chinese guideline for diagnosis and treatment of lymphoplasmacytic lymphoma/Walderström macroglobulinemia (2022)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2022Guideline
- Zanubrutinib Combined With Rituximab in the Treatment of Bing-Neel Syndrome: A Case Report.Clinical case reports · 2025Article
- Bing-Neel Syndrome in Waldenström Macroglobulinemia: Updates on Clinical Management and BTK Inhibitor Efficacy.Cancers · 2025Review
- Bing-Neel syndrome: a case series of 46 patients from the United Kingdom.Blood advances · 2025Article
- Cutaneous macroglobulinosis with Waldenström macroglobulinemia and Bing-Neel syndrome: A case report.JAAD case reports · 2025Article
- Article
- Central nervous system involvement in Waldenström macroglobulinemia: a comparative population-based study of Bing-Neel syndrome and histological transformation.Annals of hematology · 2025Article
- Bing-Neel Syndrome: A Missed Opportunity.Cureus · 2025Article
- Article
- MYD88 mutation-positive indolent B-cell lymphoma with CNS involvement: Bing-Neel syndrome mimickers.Journal of clinical and experimental hematopathology : JCEH · 2024Article
- Article
- Bing-Neel syndrome, a rare manifestation of WM; a case report and review of literature.Clinical case reports · 2024Article
- Waldenstrom Macroglobulinemia Recurrence with Bing-Neel Syndrome Presentation.Reports (MDPI) · 2024Article
- Bing-Neel syndrome: a rare neurological complication of Waldenström macroglobulinaemia.BMJ case reports · 2024Article
- Brain lesions: is there a role for internist?Internal and emergency medicine · 2024Article
- Recurrent Ischaemic Stroke Secondary to Cerebral Small Vessel Vasculopathy From Clonal B-Cell Lymphomatosis of Marginal Zone Origin.Case reports in neurological medicine · 2024Article
- Pathophysiology and Treatments of Complications of Waldenström's Macroglobulinemia.Clinical hematology international · 2024Article
- Bing-Neel Syndrome: An Unknown GCA Mimicker.Case reports in rheumatology · 2024Article
- Waldenström Macroglobulinemia - A State-of-the-Art Review: Part 1: Epidemiology, Pathogenesis, Clinicopathologic Characteristics, Differential Diagnosis, Risk Stratification, and Clinical Problems.Mediterranean journal of hematology and infectious diseases · 2024Review
- Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bing Neel syndrome is a rare disease manifestation of Waldenström's macroglobulinemia that results from infiltration of the central nervous system by malignant lymphoplasmacytic cells. In this guideline we describe the clinical symptoms, as well as the appropriate laboratory and radiological studies, that can aid in the diagnosis. The presentation of Bing Neel syndrome may be very diverse, and includes headaches, cognitive deficits, paresis, and psychiatric symptoms. The syndrome can present in patients with known Waldenström's macroglobulinemia, even in the absence of systemic progression, but also in previously undiagnosed patients. Diagnostic work-up should include cerebral spinal fluid analysis with multiparameter flow cytometry to establish B-cell clonality, protein electrophoresis and immunofixation for the detection and classification of a monoclonal protein as well as molecular diagnostic testing for immunoglobulin gene rearrangement and mutated MYD88. MRI of the brain and spinal cord is also essential. The second challenge is to expand our knowledge of prognosis and treatment outcome. Prospective clinical trials on Bing Neel syndrome patients that employ uniform treatment along with appropriate laboratory cerebral spinal fluid assessments and standardized MRI protocols will be invaluable, constituting a significant step forward in delineating treatment outcome for this intriguing disease manifestation.
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