Evidence map›Paper›PMID 27757820›Full record

Trial reportBrain imaging and behavior2017

Increased brain connectivity and activation after cognitive rehabilitation in Parkinson's disease: a randomized controlled trial.

María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, Olaia Lucas-Jiménez, Juan Carlos Gómez-Esteban, Maria Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04955275 (The Efficacy of a Remote Cognitive Remediation Therapy), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04955275 nacompletednot on this mapstarted 2021, after this paper: background citation

The Efficacy of a Remote Cognitive Remediation Therapy (CRT) Program on Parkinson's Disease

TypeinterventionalSponsorNew York Institute of TechnologyRan2021 to 2022Enrolled25ConditionsParkinson DiseaseArmsCognitive Remediation Therapy Program (BrainHQ)
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Cognitive Training in Parkinson's Disease Induces Local, Not Global, Changes in White Matter Microstructure.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

María Díez-CirardaDepartment of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Biskay, Spain.
Natalia OjedaDepartment of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Biskay, Spain.
Javier PeñaDepartment of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Biskay, Spain.
Alberto Cabrera-ZubizarretaOSATEK, MR Unit, Hospital of Galdakao, Galdakao, Basque Country, Spain.
Olaia Lucas-JiménezDepartment of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Biskay, Spain.
Juan Carlos Gómez-EstebanNeurodegenerative Unit, Biocruces Research Institute; Neurology Service, Cruces University Hospital, Bilbao, Biskay, Spain.
Maria Ángeles Gómez-BeldarrainNeurology Service, Hospital of Galdakao, Galdakao, Basque Country, Spain.
Naroa Ibarretxe-BilbaoDepartment of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Biskay, Spain. naroa.ibarretxe@deusto.es.
Universidad de Deusto · ESHospital de Galdakao · ESHospital de Cruces · ES

Funding

Department of Health of the Basque Government 2011111117Spanish Ministry of Economy and Competitiveness PSI2012-32441
6 · The paper itself

Abstract

Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy). T1-weighted, diffusion weighted and functional magnetic resonance images (fMRI) during resting-state and during a memory paradigm (with learning and recognition tasks) were acquired at pre-treatment and post-treatment. Cerebral changes were assessed with repeated measures ANOVA 2 × 2 for group x time interaction. During resting-state fMRI, the REHACOP group showed significantly increased brain connectivity between the left inferior temporal lobe and the bilateral dorsolateral prefrontal cortex compared to the control group. Moreover, during the recognition fMRI task, the REHACOP group showed significantly increased brain activation in the left middle temporal area compared to the control group. During the learning fMRI task, the REHACOP group showed increased brain activation in the left inferior frontal lobe at post-treatment compared to pre-treatment. No significant structural changes were found between pre- and post-treatment. Finally, the REHACOP group showed significant and positive correlations between the brain connectivity and activation and the cognitive performance at post-treatment. This randomized controlled trial suggests that an integrative cognitive rehabilitation program can produce significant functional cerebral changes in PD patients and adds evidence to the efficacy of cognitive rehabilitation programs in the therapeutic approach for PD.

Indexed as

Cognitive Behavioral TherapyAgedBrainBrain MappingFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedLearningMagnetic Resonance ImagingMaleMemoryMiddle AgedNeural PathwaysNeuropsychological TestsOrgan SizeBrain activationBrain connectivityCerebral changesParkinson’s diseasePlasticityRandomized controlled trial

Identifiers

PMID27757820
PMCPMC5707237
OpenAlexW2532155461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.