Evidence map›Paper›PMID 27757713›Full record

ArticleCytotechnology2016

Characterization of the growth modulatory activities of osteoblast conditioned media on cord blood progenitor cells.

Ahmad Abu-Khader, Roya Pasha, Gwendoline C D Ward, Gavin Boisjoli, Nicolas Pineault

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ahmad Abu-KhaderCentre for Innovation, Canadian Blood Services, 1800 Alta Vista, Ottawa, ON, K1G 4J5, Canada.
Roya PashaCentre for Innovation, Canadian Blood Services, 1800 Alta Vista, Ottawa, ON, K1G 4J5, Canada.
Gwendoline C D WardCentre for Innovation, Canadian Blood Services, 1800 Alta Vista, Ottawa, ON, K1G 4J5, Canada.
Gavin BoisjoliCentre for Innovation, Canadian Blood Services, 1800 Alta Vista, Ottawa, ON, K1G 4J5, Canada.
Nicolas PineaultCentre for Innovation, Canadian Blood Services, 1800 Alta Vista, Ottawa, ON, K1G 4J5, Canada. nicolas.pineault@blood.ca.
Canadian Blood Services · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engraftment outcomes are strongly correlated with the numbers of hematopoietic stem and progenitor cells (HSPC) infused. Expansion of umbilical cord blood (CB) HSPC has gained much interest lately since infusion of expanded HSPC can accelerate engraftment and improve clinical outcomes. Many novel protocols based on different expansion strategies of HSPC and their downstream derivatives are under development. Herein, we describe the production and properties of serum-free medium (SFM) conditioned with mesenchymal stromal cells derived-osteoblasts (OCM) for the expansion of umbilical CB cells and progenitors. After optimization of the conditioning length, we show that OCM increased the production of human CB total nucleated cells and CD34

Indexed as

Conditioned mediumCord bloodEx vivo expansionHematopoietic stem and progenitor cellsOsteoblasts

Identifiers

PMID27757713
PMCPMC5101297
OpenAlexW2535219711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.