Evidence map›Paper›PMID 27757680›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2017

Evaluation of a new approach to compute intervertebral disc height measurements from lateral radiographic views of the spine.

Brett T Allaire, M Clara DePaolis Kaluza, Alexander G Bruno, Elizabeth J Samelson, Douglas P Kiel, Dennis E Anderson, Mary L Bouxsein

Open access · greenAbstract read
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Description and assessment of deep ligamentum flavum-preserved modified minimally invasive transforaminal lumbar interbody fusion via unilateral biportal endoscopic assistance: a one-year retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  10. Vertebral body changes after continuous spinal distraction in scoliotic children.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
    Article
  11. A Longitudinal Study of Trunk Muscle Properties and Severity of Thoracic Kyphosis in Women and Men: The Framingham Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Brett T AllaireCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA. ballaire@bidmc.harvard.edu.
M Clara DePaolis KaluzaCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Alexander G BrunoCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Elizabeth J SamelsonInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Douglas P KielInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Dennis E AndersonCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Mary L BouxseinCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Harvard University · USBeth Israel Deaconess Medical Center · US

Funding

RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1M
Biomechanics of Vertebral Fracture: The Framingham QCT StudyR01AR053986 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BOUXSEIN, MARY L · 2007 to 2016
$5.4M
Mechansims and Clinical Importance of Hyperkyphosis:The Framingham StudyR01AG041658 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI SAMELSON, ELIZABETH J · 2011 to 2015
$2.6M
Volumetric Bone Density and Vascular Calcification: The Framingham QCT StudyK01AR053118 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI SAMELSON, ELIZABETH J · 2007 to 2011
$481k
Biomechanics of the Vertebral Fracture CascadeF31AG041629 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRUNO, ALEXANDER GREGORY · 2011 to 2015
$154k
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INIAMS NIH HHS K01 AR053118NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR053986NIA NIH HHS F31 AG041629NIA NIH HHS R01 AG041658
6 · The paper itself

Abstract

purposeCurrent standard methods to quantify disc height, namely distortion compensated Roentgen analysis (DCRA), have been mostly utilized in the lumbar and cervical spine and have strict exclusion criteria. Specifically, discs adjacent to a vertebral fracture are excluded from measurement, thus limiting the use of DCRA in studies that include older populations with a high prevalence of vertebral fractures. Thus, we developed and tested a modified DCRA algorithm that does not depend on vertebral shape.

methodsParticipants included 1186 men and women from the Framingham Heart Study Offspring and Third Generation Multidetector CT Study. Lateral CT scout images were used to place 6 morphometry points around each vertebra at 13 vertebral levels in each participant. Disc heights were calculated utilizing these morphometry points using DCRA methodology and our modified version of DCRA, which requires information from fewer morphometry points than the standard DCRA.

resultsModified DCRA and standard DCRA measures of disc height are highly correlated, with concordance correlation coefficients above 0.999. Both measures demonstrate good inter- and intra-operator reproducibility. 13.9 % of available disc heights were not evaluable or excluded using the standard DCRA algorithm, while only 3.3 % of disc heights were not evaluable using our modified DCRA algorithm.

conclusionsUsing our modified DCRA algorithm, it is not necessary to exclude vertebrae with fracture or other deformity from disc height measurements as in the standard DCRA. Modified DCRA also yields identical measurements to the standard DCRA. Thus, the use of modified DCRA for quantitative assessment of disc height will lead to less missing data without any loss of accuracy, making it a preferred alternative to the current standard methodology.

Indexed as

AlgorithmsAgedCross-Sectional StudiesFemaleHumansIntervertebral DiscMaleMiddle AgedMultidetector Computed TomographyReproducibility of ResultsSoftwareSpineDisc heightIntervertebral discRadiographSpine

Identifiers

PMID27757680
PMCPMC5350627
OpenAlexW2533352651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.