Trial reportEuropean journal of nutrition2018
Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial.
Trial report in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06595082 (Evaluation of the Consumption of Lupins in Brine on Metabolic Markers in Healthy Individuals), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Consumption of Lupins in Brine on Metabolic Markers in Healthy Individuals
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Protein intake and cardiovascular diseases: an umbrella review of systematic reviews for the evidence-based guideline on protein intake of the German Nutrition Society.European journal of nutrition · 2025Pooled it
- Pooled it
- Adiponectin and 8-epi-PGFThe British journal of nutrition · 2022Trial
- Trial
- Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications.Biomedicines · 2026Review
- Soy and the gut microbiome: a bi-directional relationship shaping nutrition and health.European journal of nutrition · 2026Review
- Ultra-processed Plant Foods: Are They Worse than their Unprocessed Animal-Based Counterparts?Current nutrition reports · 2025Review
- Diet and Lipid-Lowering Nutraceuticals in Pediatric Patients with Familial Hypercholesterolemia.Children (Basel, Switzerland) · 2024Review
- Gender-specific effects of soybean consumption on cardiovascular events in elderly individuals from rural Northeast China - a prospective cohort study.BMC geriatrics · 2023Article
- The Effect of Dietary Pattern on Metabolic Syndrome in a Suburban Population in Shanghai, China.Nutrients · 2023Article
- Association of legumes and nuts consumption with metabolic health status in Iranian overweight and obese adolescents.Scientific reports · 2023Article
- New Advances in Metabolic Syndrome, from Prevention to Treatment: The Role of Diet and Food.Nutrients · 2023Review
- Relationships of beans intake with chronic kidney disease in rural adults: A large-scale cross-sectional study.Frontiers in nutrition · 2023Article
- Review
- Usual intake of dietary isoflavone and its major food sources in Koreans: Korea National Health and Nutrition Examination Survey 2016-2018 data.Nutrition research and practice · 2022Review
- Food as medicine? Exploring the impact of providing healthy foods on adherence and clinical and economic outcomes.Exploratory research in clinical and social pharmacy · 2022Article
- Nutraceuticals for Dyslipidaemia and Glucometabolic Diseases: What the Guidelines Tell Us (and Do Not Tell, Yet).Nutrients · 2022Review
- Soy Food Intake Associated with Obesity and Hypertension in Children and Adolescents in Guangzhou, Southern China.Nutrients · 2022Article
- Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome.Molecules (Basel, Switzerland) · 2021Review
- Soy intake and chronic disease risk: findings from prospective cohort studies in Japan.European journal of clinical nutrition · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular diseases are currently the commonest cause of death worldwide. Different strategies for their primary prevention have been planned, taking into account the main known risk factors, which include an atherogenic lipid profile and visceral fat excess.
methodsThe study was designed as a randomized, parallel, single-center study with a nutritional intervention duration of 12 weeks. Whole soy foods corresponding to 30 g/day soy protein were given in substitution of animal foods containing the same protein amount.
resultsSoy nutritional intervention resulted in a reduction in the number of MetS features in 13/26 subjects. Moreover, in the soy group we observed a significant improvement of median percentage changes for body weight (-1.5 %) and BMI (-1.5 %), as well as for atherogenic lipid markers, namely TC (-4.85 %), LDL-C (-5.25 %), non-HDL-C (-7.14 %) and apoB (-14.8 %). Since the majority of the studied variables were strongly correlated, three factors were identified which explained the majority (52 %) of the total variance in the whole data set. Among them, factor 1, which loaded lipid and adipose variables, explained the 22 % of total variance, showing a statistically significant difference between treatment arms (p = 0.002).
conclusionsThe inclusion of whole soy foods (corresponding to 30 g/day protein) in a lipid-lowering diet significantly improved a relevant set of biomarkers associated with cardiovascular risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.