Evidence map›Paper›PMID 27757581›Full record

ArticlePflugers Archiv : European journal of physiology2016

Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells.

Florentina Sophie Ferstl, Alice Miriam Kitay, Rebecca Marion Trattnig, Abrar Alsaihati, John Peter Geibel

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Florentina Sophie FerstlDepartment of Surgery, School of Medicine, Yale University, BML 238, 310 Cedar St., New Haven, CT, 06511, USA.
Alice Miriam KitayDepartment of Surgery, School of Medicine, Yale University, BML 238, 310 Cedar St., New Haven, CT, 06511, USA.
Rebecca Marion TrattnigDepartment of Surgery, School of Medicine, Yale University, BML 238, 310 Cedar St., New Haven, CT, 06511, USA.
Abrar AlsaihatiDepartment of Surgery, School of Medicine, Yale University, BML 238, 310 Cedar St., New Haven, CT, 06511, USA.
John Peter GeibelDepartment of Surgery, School of Medicine, Yale University, BML 238, 310 Cedar St., New Haven, CT, 06511, USA. john.geibel@yale.edu.
Yale University · USOtto-von-Guericke University Magdeburg · DEParacelsus Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged exposure to gastric acid is a leading cause of gastroesophageal reflux disease (GERD) and esophagitis. With the ever increasing number of patients showing insensitivity to proton-pump-inhibitor (PPI) therapy with recurrence of symptoms over time, alternative treatment options remain an important issue. Previous studies from our laboratory have shown that a zinc sulfate salt can inhibit HCl generation at the cellular level of the parietal cell. In this paper, we examine the difference between two hydration forms of ZnSO

Indexed as

AnimalsBiological TransportBumetanideCarbacholGastric AcidHistamineMaleParietal Cells, GastricRatsRats, Sprague-DawleySolute Carrier Family 12, Member 2Zinc SulfateBumetanideCarbacholHistamineSlc12a2 protein, ratSolute Carrier Family 12, Member 2Zinc SulfateBumetanideGastric acid secretionNewport greenNKCC1 co-transporterStomach

Identifiers

PMID27757581
OpenAlexW2533727722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.