ArticleJournal of gastroenterology2017
Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population.
Article in Journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024Guideline
- Risk factors for lymph node metastasis in T1 esophageal squamous cell carcinoma: A systematic review and meta-analysis.World journal of gastroenterology · 2021Pooled it
- Clinicopathological features in T1 adenocarcinoma of the esophagogastric junction: a new perspective on tumor localization.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- The poorly differentiated component in endoscopic biopsy predicts submucosal invasion in superficial Barrett's esophageal adenocarcinoma.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Review
- Factors influencing lateral margin diagnosis challenges in Barrett's esophageal cancer: a bicenter retrospective study in Japan.Clinical endoscopy · 2025Article
- Cancer risk by length of Barrett's esophagus in Japanese population: a nationwide multicenter retrospective cohort study.Journal of gastroenterology · 2024Article
- Adenocarcinoma of the esophagogastric junction: characteristics of female patients and young adult patients based on a 12-year retrospective and prospective multicenter clinicoepidemiological cohort study in Japan.BMC gastroenterology · 2024Article
- Risk stratification for synchronous/metachronous recurrence after endoscopic submucosal dissection for Barrett's esophageal adenocarcinoma using the length of Barrett's esophagus.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Long- vs short-segment Barrett's esophagus-derived adenocarcinoma: clinical features and outcomes of endoscopic submucosal dissection.Surgical endoscopy · 2024Article
- Article
- Usefulness of the Japan Esophageal Society Classification of Barrett's Esophagus for Diagnosing the Lateral Extent of Superficial Short-Segment Barrett's Esophageal Cancer.Gastrointestinal tumors · 2022Article
- HER2-Positive Gastroesophageal Cancers Are Associated with a Higher Risk of Brain Metastasis.Cancers · 2022Article
- An extra 1-cm margin during endoscopic submucosal dissection can control subsquamous tumor extension of esophagogastric junction adenocarcinoma.Endoscopy international open · 2022Article
- Long-term outcomes of endoscopic mucosal resection for early-stage esophageal adenocarcinoma.Surgical endoscopy · 2022Article
- Review
- Barrett's esophagus: Review of natural history and comparative efficacy of endoscopic and surgical therapies.World journal of gastrointestinal oncology · 2022Review
- Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study.Internal medicine (Tokyo, Japan) · 2022Article
- Endoscopic Submucosal Dissection for Superficial Barrett's Neoplasia in Korea: a Single-Center Experience.Journal of gastric cancer · 2021Article
- Clinicopathologic correlations of superficial esophageal adenocarcinoma in endoscopic submucosal dissection specimens.Diagnostic pathology · 2021Article
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Authors and funding
32 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the specific risks of metastasis in esophageal adenocarcinoma in relation to invasion depth or other pathologic factors.
methodsWe conducted a multicenter retrospective study in 13 high-volume centers in Japan from January 2000 to October 2014 to elucidate the risk of metastasis of esophageal adenocarcinoma. A total of 458 patients (217 surgically resected and 241 endoscopically resected) with esophageal adenocarcinoma or esophagogastric adenocarcinoma involving the esophagus were included. Metastasis was considered positive if there was histologically confirmed metastasis in the surgical specimen or clinically confirmed metastasis during follow-up. Metastasis was considered negative if no metastasis was identified in resected specimens and during follow-up in patients treated surgically or no metastasis during follow-up for >5 years in patients treated by endoscopic resection.
resultsMetastasis was identified in 72 patients. Multivariate analysis confirmed lymphovascular involvement [odds ratio (OR) 6.20; 95 % confidence interval (CI) 3.12-12.32; p < 0.001], a poorly differentiated component (OR 3.69; 95 % CI 1.92-7.10; p < 0.001), and lesion size >30 mm (OR 3.12; 95 % CI 1.63-5.97; p = 0.001) as independent risk factors for metastasis. No metastasis was detected in patients with mucosal cancer without lymphovascular involvement and a poorly differentiated component (0/186 lesions) or in patients with cancer invading the submucosa (1-500 µm) without lymphovascular involvement, a poorly differentiated component, and ≤30 mm (0/32 lesions).
conclusionsMucosal and submucosal cancers (1-500 µm invasion) without risk factors have a low incidence of metastasis and may thus be good candidates for endoscopic resection.
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