Evidence map›Paper›PMID 27757426›Full record

ArticleScience advances2016

TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1.

Mohammad B Hossain, Rehnuma Shifat, David G Johnson, Mark T Bedford, Konrad R Gabrusiewicz, Nahir Cortes-Santiago, Xuemei Luo, Zhimin Lu, Ravesanker Ezhilarasan, Erik P Sulman and 7 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Histone Phosphorylation in DNA Damage Response.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. A high-throughputActa pharmaceutica Sinica. B · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Preserving genome integrity and function: the DNA damage response and histone modifications.Critical reviews in biochemistry and molecular biology · 2019
    Review
  16. Protein phosphatases in chromatin structure and function.Biochimica et biophysica acta. Molecular cell research · 2019
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Mohammad B HossainDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rehnuma ShifatDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
David G JohnsonDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, USA.
Mark T BedfordDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, USA.ORCID 0000-0002-8899-1050
Konrad R GabrusiewiczDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Nahir Cortes-SantiagoDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xuemei LuoBiomolecular Resource Facility, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-8292-6733
Zhimin LuDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ravesanker EzhilarasanDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-1353-8307
Erik P SulmanDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hong JiangDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Shawn S C LiDepartment of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Frederick F LangDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jessica TylerDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, USA.
Mien-Chie HungDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan.
Juan FueyoDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Candelaria Gomez-ManzanoDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
The University of Texas MD Anderson Cancer Center · USThe University of Texas Medical Branch at Galveston · USWestern University · CA

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo · 2008 to 2026
$41.2M
Chromatin's Role in Repair of Radiation-induced Damage.R01CA095641 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2002 to 2023
$5.2M
DUAL ROLE OF E2F1 IN TUMORIGENESISR01CA079648 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JOHNSON, DAVID G. · 1999 to 2014
$4.7M
Role of TEMs in brain tumor dispersalR01NS069964 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GOMEZ-MANZANO, CANDELARIA, MARINI, FRANK C. · 2010 to 2014
$1.7M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA127001NCI NIH HHS R01 CA079648NCI NIH HHS R01 CA095641NINDS NIH HHS R01 NS069964
6 · The paper itself

Abstract

DNA repair pathways enable cancer cells to survive DNA damage induced after genotoxic therapies. Tyrosine kinase receptors (TKRs) have been reported as regulators of the DNA repair machinery. TIE2 is a TKR overexpressed in human gliomas at levels that correlate with the degree of increasing malignancy. Following ionizing radiation, TIE2 translocates to the nucleus, conferring cells with an enhanced nonhomologous end-joining mechanism of DNA repair that results in a radioresistant phenotype. Nuclear TIE2 binds to key components of DNA repair and phosphorylates H4 at tyrosine 51, which, in turn, is recognized by the proto-oncogene ABL1, indicating a role for nuclear TIE2 as a sensor for genotoxic stress by action as a histone modifier. H4Y51 constitutes the first tyrosine phosphorylation of core histones recognized by ABL1, defining this histone modification as a direct signal to couple genotoxic stress with the DNA repair machinery.

Indexed as

DNA DamageAngiotensin ICell Line, TumorDNA End-Joining RepairHistonesHumansProtein BindingProtein TransportProto-Oncogene MasProto-Oncogene Proteins c-ablRadiation, IonizingRadiation ToleranceReceptor, TIE-2TyrosineAngiotensin IHistonesMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins c-ablReceptor, TIE-2TyrosineABL1ANG1Cell biologyDNA repairNHEJoncogenesTIE2

Identifiers

PMID27757426
PMCPMC5065225
OpenAlexW2316346096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.