Evidence map›Paper›PMID 27757353›Full record

ArticlePlastic and reconstructive surgery. Global open2016

Lipedema: A Relatively Common Disease with Extremely Common Misconceptions.

Donald W Buck, Karen L Herbst

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07061808 (The Reliability and Validity of the Turkish Version of the Lipedema Screening Questionnaire), which is not on this map. Cited by 85 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 5 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07061808 completednot on this mapstarted 2022, after this paper: background citation

The Reliability and Validity of the Turkish Version of the Lipedema Screening Questionnaire

TypeobservationalSponsorGazi UniversityRan2022 to 2023Enrolled59ConditionsLipedema, WomenArmsLipedema Screening Questionnaire
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 5 syntheses or guidelines pooled it, 196 citations in OpenAlex.

  1. Pooled it
  2. Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
  3. Pooled it
  4. [Differential diagnostics of lipedema and lymphedema : A practical guideline].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018
    Guideline
  5. Guideline
  6. Article
  7. Article
  8. Myocardial, Valvular, and Vascular Abnormalities in Lipedema.Reviews in cardiovascular medicine · 2026
    Review
  9. Article
  10. Lymphoscintigraphic Findings in Patients With Lipedema: A Systematic Review.Plastic and reconstructive surgery. Global open · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Donald W BuckDivision of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo.; and Department of Medicine, University of Arizona, Banner University Medical Center, Tucson, Ariz.
Karen L HerbstDivision of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo.; and Department of Medicine, University of Arizona, Banner University Medical Center, Tucson, Ariz.
Banner - University Medical Center Tucson · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipedema, or adiposis dolorosa, is a common adipose tissue disorder that is believed to affect nearly 11% of adult women worldwide. It is characterized most commonly by disproportionate adipocyte hypertrophy of the lower extremities, significant tenderness to palpation, and a failure to respond to extreme weight loss modalities. Women with lipedema report a rapid growth of the lipedema subcutaneous adipose tissue in the setting of stress, surgery, and/or hormonal changes. Women with later stages of lipedema have a classic "column leg" appearance, with masses of nodular fat, easy bruising, and pain. Despite this relatively common disease, there are few physicians who are aware of it. As a result, patients are often misdiagnosed with lifestyle-induced obesity, and/or lymphedema, and subjected to unnecessary medical interventions and fat-shaming. Diagnosis is largely clinical and based on criteria initially established in 1951. Treatment of lipedema is effective and includes lymphatic support, such as complete decongestive therapy, and specialized suction lipectomy to spare injury to lymphatic channels and remove the diseased lipedema fat. With an incidence that may affect nearly 1 in 9 adult women, it is important to generate appropriate awareness, conduct additional research, and identify better diagnostic and treatment modalities for lipedema so these women can obtain the care that they need and deserve.

Identifiers

PMID27757353
PMCPMC5055019
OpenAlexW2527120181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.