Evidence map›Paper›PMID 27757113›Full record

ArticleFrontiers in immunology2016

Minimal Residual Disease Detection and Evolved

Jinghua Wu, Shan Jia, Changxi Wang, Wei Zhang, Sixi Liu, Xiaojing Zeng, Huirong Mai, Xiuli Yuan, Yuanping Du, Xiaodong Wang and 7 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Next-Generation Sequencing in Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2019
    Review
  11. Article
  12. Article
  13. T Cell Receptor Profiling in Type 1 Diabetes.Current diabetes reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jinghua WuBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China.
Shan JiaHematology and Oncology Department, Shenzhen Children's Hospital , Shenzhen , China.
Changxi WangBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China.
Wei ZhangBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China.
Sixi LiuHematology and Oncology Department, Shenzhen Children's Hospital , Shenzhen , China.
Xiaojing ZengBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China.
Huirong MaiHematology and Oncology Department, Shenzhen Children's Hospital , Shenzhen , China.
Xiuli YuanHematology and Oncology Department, Shenzhen Children's Hospital , Shenzhen , China.
Yuanping DuBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China.
Xiaodong WangHematology and Oncology Department, Shenzhen Children's Hospital , Shenzhen , China.
Xueyu HongBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China.
Xuemei LiBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China.
Feiqiu WenHematology and Oncology Department, Shenzhen Children's Hospital , Shenzhen , China.
Xun XuBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China.
Jianhua PanKingMed Diagnostics , Guangzhou , China.
Changgang LiHematology and Oncology Department, Shenzhen Children's Hospital , Shenzhen , China.
Xiao LiuBGI-Shenzhen, Shenzhen, China; China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China; Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute B lymphoblastic leukemia (B-ALL) is one of the most common types of childhood cancer worldwide and chemotherapy is the main treatment approach. Despite good response rates to chemotherapy regiments, many patients eventually relapse and minimal residual disease (MRD) is the leading risk factor for relapse. The evolution of leukemic clones during disease development and treatment may have clinical significance. In this study, we performed immunoglobulin heavy chain (

Indexed as

acute B lymphoblast leukemiaclonal evolutionhigh throughput sequencingIGHminimal residual disease

Identifiers

PMID27757113
PMCPMC5048610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.