ArticleFrontiers in human neuroscience2016
Functional Connectivity Abnormalities of Brain Regions with Structural Deficits in Young Adult Male Smokers.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Functional Connectivity Disruptions in Grey Matter Volume-Altered Brain Regions Among Male Smokers: A Neuroimaging Study.Addiction biology · 2025Pooled it
- The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis.Psychopharmacology · 2021Pooled it
- Gray and white matter morphology in substance use disorders: a neuroimaging systematic review and meta-analysis.Translational psychiatry · 2021Pooled it
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers.BMC psychiatry · 2025Article
- Resting-state functional connectivity and structural differences between smokers and healthy non-smokers.Scientific reports · 2024Article
- Connectome-based predictive modeling of smoking severity using individualized structural covariance network in smokers.Frontiers in neuroscience · 2023Article
- Comparison of frontostriatal circuits in adolescent nicotine addiction and internet gaming disorder.Journal of behavioral addictions · 2022Review
- Dynamic Neuroimaging Biomarkers of Smoking in Young Smokers.Frontiers in psychiatry · 2020Article
- 12 h Abstinence-Induced ERP Changes in Young Smokers: Electrophysiological Evidence From a Go/NoGo Study.Frontiers in psychology · 2019Article
- Region-Specific Changes of Insular Cortical Thickness in Heavy Smokers.Frontiers in human neuroscience · 2019Article
- The left dorsolateral prefrontal cortex and caudate pathway: New evidence for cue-induced craving of smokers.Human brain mapping · 2017Article
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking is one of the most prevalent dependence disorders. Previous studies have detected structural and functional deficits in smokers. However, few studies focused on the changes of resting state functional connectivity (RSFC) of the brain regions with structural deficits in young adult smokers. Twenty-six young adult smokers and 26 well-matched healthy non-smokers participated in our study. Voxel-based morphometry (VBM) and RSFC were employed to investigate the structural and functional changes in young adult smokers. Compared with healthy non-smokers, young smokers showed increased gray matter (GM) volume in the left putamen and decreased GM volume in the left anterior cingulate cortex (ACC). Moreover, GM volume in the left ACC has a negative correlation trend with pack-years and GM volume in the left putamen was positively correlated with pack-years. The left ACC and putamen with abnormal volumes were chosen as the regions of interest (ROIs) for the RSFC analysis. We found that smokers showed increased RSFC between the left ACC and right amygdala and between the left putamen and right anterior insula. We revealed structural and functional deficits within the frontostriatal circuits in young smokers, which may shed new insights into the neural mechanisms of smoking.
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