ReviewNature reviews. Gastroenterology & hepatology2016
Problems with extracellular recording of electrical activity in gastrointestinal muscle.
Review in Nature reviews. Gastroenterology & hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Gastric Biofeedback in Virtual Reality: Feasibility, Efficacy and Self-Reported Experience.Applied psychophysiology and biofeedback · 2026Trial
- Gastric slow-wave morphology in health and disease.Digestive diseases and sciences · 2026Article
- Stretchable thin-film metal electronics enabled by multilayered nanomembranes.bioRxiv : the preprint server for biology · 2025Article
- Local Myoelectric Sensing During Human Colonic Tissue Perfusion.Diagnostics (Basel, Switzerland) · 2024Article
- Surface mapping of gastric motor functions using MRI: a comparative study between humans and rats.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- CaPhysiological reviews · 2024Review
- Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract.World journal of gastrointestinal surgery · 2022Review
- Arecoline hydrobromide enhances jejunum smooth muscle contractility via voltage-dependent potassium channels in W/Wv mice.Physiological research · 2021Article
- Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording.Nature nanotechnology · 2019Article
- Advances in the physiology of gastric emptying.Neurogastroenterology and motility · 2019Review
- Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.Advances in experimental medicine and biology · 2019Review
- Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals.Micromachines · 2018Review
- Electrical stimulation of gut motility guided by an in silico model.Journal of neural engineering · 2017Article
- Power comes from technical fidelity, not from ease of use.Nature reviews. Gastroenterology & hepatology · 2017Article
- The powerful advantages of extracellular electrical recording.Nature reviews. Gastroenterology & hepatology · 2017Article
- Correct techniques for extracellular recordings of electrical activity in gastrointestinal muscle.Nature reviews. Gastroenterology & hepatology · 2017Article
- Extracellular gastrointestinal electrical recordings: movement not electrophysiology.Nature reviews. Gastroenterology & hepatology · 2017Article
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Motility patterns of the gastrointestinal tract are important for efficient processing of nutrients and waste. Peristalsis and segmentation are based on rhythmic electrical slow waves that generate the phasic contractions fundamental to gastrointestinal motility. Slow waves are generated and propagated actively by interstitial cells of Cajal (ICC), and these events conduct to smooth muscle cells to elicit excitation-contraction coupling. Extracellular electrical recording has been utilized to characterize slow-wave generation and propagation and abnormalities that might be responsible for gastrointestinal motility disorders. Electrode array recording and digital processing are being used to generate data for models of electrical propagation in normal and pathophysiological conditions. Here, we discuss techniques of extracellular recording as applied to gastrointestinal organs and how mechanical artefacts might contaminate these recordings and confound their interpretation. Without rigorous controls for movement, current interpretations of extracellular recordings might ascribe inaccurate behaviours and electrical anomalies to ICC networks and gastrointestinal muscles, bringing into question the findings and validity of models of gastrointestinal electrophysiology developed from these recordings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.