ArticleScientific reports2016
Label-free, rapid and quantitative phenotyping of stress response in E. coli via ramanome.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Precise probiotic therapy: Advances, bottlenecks, and the road to microbiome-informed nutrition.Gut microbes · 2026Review
- RamEx: an R package for high-throughput microbial ramanome analyses with accurate quality assessment.Microbiome · 2026Article
- Live-cell omics with Raman spectroscopy.Microscopy (Oxford, England) · 2025Review
- Enhancing Open-World Bacterial Raman Spectra Identification by Feature Regularization for Improved Resilience against Unknown Classes.Chemical & biomedical imaging · 2024Article
- SERSomes for metabolic phenotyping and prostate cancer diagnosis.Cell reports. Medicine · 2024Article
- Rapid identification of lactic acid bacteria at species/subspecies level via ensemble learning of Ramanomes.Frontiers in microbiology · 2024Article
- Rapid Mycobacterium abscessus antimicrobial susceptibility testing based on antibiotic treatment response mapping via Raman Microspectroscopy.Annals of clinical microbiology and antimicrobials · 2023Article
- Robust Spontaneous Raman Flow Cytometry for Single-Cell Metabolic Phenome Profiling via pDEP-DLD-RFC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Nanogap traps for passive bacteria concentration and single-point confocal Raman spectroscopy.Biomicrofluidics · 2023Article
- Opportunities in optical and electrical single-cell technologies to study microbial ecosystems.Frontiers in microbiology · 2023Review
- Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST-R.mLife · 2022Article
- Discriminating cell line specific features of antibiotic-resistant strains of Escherichia coli from Raman spectra via machine learning analysis.Journal of biophotonics · 2022Article
- Discrimination of Stressed and Non-Stressed Food-Related Bacteria Using Raman-Microspectroscopy.Foods (Basel, Switzerland) · 2022Article
- Identification of antibiotic resistance and virulence-encoding factors in Klebsiella pneumoniae by Raman spectroscopy and deep learning.Microbial biotechnology · 2022Article
- Raman-Deuterium Isotope Probing and Metagenomics Reveal the Drought Tolerance of the Soil Microbiome and Its Promotion of Plant Growth.mSystems · 2022Article
- Rapid, Label-Free Prediction of Antibiotic Resistance inInternational journal of molecular sciences · 2022Article
- Single-cell Raman spectroscopy identifiesFrontiers in microbiology · 2022Article
- Assessing Efficacy of Clinical Disinfectants for Pathogenic Fungi by Single-Cell Raman Microspectroscopy.Frontiers in cellular and infection microbiology · 2022Article
- Phenotypic convergence of bacterial adaption to sub-lethal antibiotic treatment.Frontiers in cellular and infection microbiology · 2022Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid profiling of stress-response at single-cell resolution yet in a label-free, non-disruptive and mechanism-specific manner can lead to many new applications. We propose a single-cell-level biochemical fingerprinting approach named "ramanome", which is the collection of Single-cell Raman Spectra (SCRS) from a number of cells randomly selected from an isogenic population at a given time and condition, to rapidly and quantitatively detect and characterize stress responses of cellular population. SCRS of Escherichia coli cells are sensitive to both exposure time (eight time points) and dosage (six doses) of ethanol, with detection time as early as 5 min and discrimination rate of either factor over 80%. Moreover, the ramanomes upon six chemical compounds from three categories, including antibiotics of ampicillin and kanamycin, alcohols of ethanol and n-butanol and heavy metals of Cu
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