Evidence map›Paper›PMID 27756899›Full record

ArticleScientific reports2016

A rare schizophrenia risk variant of CACNA1I disrupts Ca

A Andrade, J Hope, A Allen, V Yorgan, D Lipscombe, J Q Pan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  9. The T-type calcium channelosome.Pflugers Archiv : European journal of physiology · 2024
    Review
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  19. Article
  20. Investigation ofFrontiers in molecular neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

A AndradeDepartment of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, Durham, NH 03824, USA.
J HopeStanley Center of Psychiatric Research, Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.
A AllenStanley Center of Psychiatric Research, Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.
V YorganBrown Institute for Brain Science, Providence, RI 02912, USA.
D LipscombeBrown Institute for Brain Science, Providence, RI 02912, USA.
J Q PanStanley Center of Psychiatric Research, Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.
Broad Institute · USProvidence College · USUniversity of New Hampshire · US

Funding

Voltage-Gated Calcium Channels in Nociceptors and MechanoreceptorsR01NS055251 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE · 2006 to 2025
$9.1M
Interdisciplinary Vision Training ProgramT32EY018080 · NEI · BROWN UNIVERSITY · PI PARADISO, MICHAEL A · 2007 to 2021
$1.9M
Neuroscience Advanced Predoctoral Institutional Training GrantT32NS062443 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE, MOORE, CHRISTOPHER I · 2008 to 2018
$1.8M
Role of Gi/o-Protein Inhibition of CaV2.2 Channels in Anxiety BehaviorR00MH099405 · NIMH · UNIVERSITY OF NEW HAMPSHIRE · PI ANDRADE, ARTURO · 2015 to 2017
$738k
Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human NeuronsR21MH099448 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN · 2012 to 2013
$467k
NEI NIH HHS T32 EY018080NIMH NIH HHS R00 MH099405NIMH NIH HHS R21 MH099448NINDS NIH HHS R01 NS055251NINDS NIH HHS T32 NS062443
6 · The paper itself

Abstract

CACNA1I is a candidate schizophrenia risk gene. It encodes the pore-forming human Ca

Indexed as

Calcium Channels, T-TypeMutation, MissenseSchizophreniaAmino Acid SubstitutionHEK293 CellsHumansNeuronsRisk FactorsCACNA1I protein, humanCalcium Channels, T-Type

Identifiers

PMID27756899
PMCPMC5069464
OpenAlexW2537603747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.