Evidence map›Paper›PMID 27756843›Full record

ArticleThe Journal of biological chemistry2016

Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.

Kelsey S Kalous, Sarah L Wynia-Smith, Michael D Olp, Brian C Smith

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Nitric Oxide Signaling and Sensing in Age-Related Diseases.Antioxidants (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Article
  9. Occludin: a gatekeeper of brain Infection by HIV-1.Fluids and barriers of the CNS · 2023
    Review
  10. Review
  11. The differing effects of a dual acting regulator on SIRT1.Frontiers in molecular biosciences · 2023
    Article
  12. Review
  13. Review
  14. Review
  15. Genes · 2021
    Review
  16. Observational
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelsey S KalousFrom the Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.
Sarah L Wynia-SmithFrom the Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.
Michael D OlpFrom the Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.
Brian C SmithFrom the Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 brismith@mcw.edu.ORCID http://orcid.org/0000-0001-6330-2768
Medical College of Wisconsin · US

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
American Heart Association-American Stroke Association 15SDG25830057NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

The sirtuin family of proteins catalyze the NAD

Indexed as

AnimalsCattleCysteineEnzyme StabilityHumansNADNitrosationSirtuin 1S-NitrosoglutathioneZincCysteineNADSIRT1 protein, humanSirtuin 1S-NitrosoglutathioneZincacetylationallosteric regulationenzyme inactivationinhibition mechanismnicotinamide adenine dinucleotide (NAD)nitric oxidenitrosationnitrosylationsirtuin 1 (SIRT1)zinc

Identifiers

PMID27756843
PMCPMC5207242
OpenAlexW2535718125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.