Evidence map›Paper›PMID 27756562›Full record

ArticleBioorganic & medicinal chemistry letters2016

Cyclic non-opioid dynorphin A analogues for the bradykinin receptors.

Yeon Sun Lee, Michael Remesic, Cyf Ramos-Colon, Sara M Hall, Alexander Kuzmin, David Rankin, Frank Porreca, Josephine Lai, Victor J Hruby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yeon Sun LeeDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA. Electronic address: yeon@email.arizona.edu.
Michael RemesicDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
Cyf Ramos-ColonDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
Sara M HallDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
Alexander KuzminDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
David RankinDepartment of Pharmacology, University of Arizona, Tucson, AZ 85719, USA.
Frank PorrecaDepartment of Pharmacology, University of Arizona, Tucson, AZ 85719, USA.
Josephine LaiDepartment of Pharmacology, University of Arizona, Tucson, AZ 85719, USA.
Victor J HrubyDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
University of Arizona · US

Funding

THERAPEUTIC PROFILES OF OPIOID DELTA RECEPTORS--NEW MODALITIESP01DA006284 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 1989 to 2015
$14.8M
NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAINR01DA013449 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 2000 to 2015
$6.8M
NIDA NIH HHS P01 DA006284NIDA NIH HHS R01 DA013449
6 · The paper itself

Abstract

Nerve injury and inflammation cause up-regulation of an endogenous opioid ligand, dynorphin A (Dyn A), in the spinal cord resulting in hyperalgesia via the interaction with bradykinin receptors (BRs). This is a non-opioid neuroexcitatory effect that cannot be blocked by opioid antagonists. Our systematic structure-activity relationships study on Dyn A identified lead ligands 1 and 4, along with the key structural feature (i.e. amphipathicity) for the BRs. However, the ligands showed very low metabolic stability in plasma (t

Indexed as

Amino Acid SequenceAnalgesics, Non-NarcoticAnimalsBradykinin Receptor AntagonistsCyclizationDynorphinsLigandsRatsReceptors, BradykininStructure-Activity RelationshipAnalgesics, Non-NarcoticBradykinin Receptor AntagonistsDynorphinsLigandsReceptors, BradykininAmphipathicityBradykinin receptorsCyclic ligandsMetabolic stabilityNon-opioid dynorphin AStructure–activity relationship

Identifiers

PMID27756562
PMCPMC5159310
OpenAlexW2528313429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.