ArticleBMC genomics2016
Comparative analysis of a sex chromosome from the blackchin tilapia, Sarotherodon melanotheron.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Before the East African Radiation: Sex Chromosome Systems in Basal Haplotilapiine Cichlids.Genome biology and evolution · 2026Article
- Feasibility study of core training in knee injury recovery.Turkish journal of physical medicine and rehabilitation · 2025Article
- Characterization of the sex determining region and development of a molecular sex identification method in a Salangid fish.BMC genomics · 2024Article
- Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus.Science China. Life sciences · 2024Article
- A pheromone receptor in cichlid fish mediates attraction to females but inhibits male parental care.Current biology : CB · 2024Article
- Absence ofInternational journal of molecular sciences · 2022Article
- Sex determination mechanisms and sex control approaches in aquaculture animals.Science China. Life sciences · 2022Review
- Article
- Identification of sex chromosome and sex-determining gene of southern catfish (Proceedings. Biological sciences · 2022Article
- First identification of two co-existing genome-wide significant sex quantitative trait loci (QTL) in red tilapia using integrative QTL mapping.Zoological research · 2022Article
- RADSex: A computational workflow to study sex determination using restriction site-associated DNA sequencing data.Molecular ecology resources · 2021Article
- Gene Variant ofInternational journal of molecular sciences · 2021Article
- Origin of a Giant Sex Chromosome.Molecular biology and evolution · 2021Article
- A Chromosome-Level Genome Assembly of Mozambique Tilapia (Frontiers in genetics · 2021Article
- Disagreement in FMolecular ecology resources · 2020Article
- Sex chromosome and sex locus characterization in goldfish, Carassius auratus (Linnaeus, 1758).BMC genomics · 2020Article
- Characterization of a Y-specific duplication/insertion of the anti-Mullerian hormone type II receptor gene based on a chromosome-scale genome assembly of yellow perch, Perca flavescens.Molecular ecology resources · 2020Article
- Preferential Mapping of Sex-Biased Differentially-Expressed Genes of Larvae to the Sex-Determining Region of Flathead Grey Mullet (Frontiers in genetics · 2020Article
- Characterization of sex chromosomes in three deeply diverged species of Pseudocrenilabrinae (Teleostei: Cichlidae).Hydrobiologia · 2019Article
- Chromosome-scale assemblies reveal the structural evolution of African cichlid genomes.GigaScience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInversions and other structural polymorphisms often reduce the rate of recombination between sex chromosomes, making it impossible to fine map sex-determination loci using traditional genetic mapping techniques. Here we compare distantly related species of tilapia that each segregate an XY system of sex-determination on linkage group 1. We use whole genome sequencing to identify shared sex-patterned polymorphisms, which are candidates for the ancestral sex-determination mutation.
resultsWe found that Sarotherodon melanotheron segregates an XY system on LG1 in the same region identified in Oreochromis niloticus. Both species have higher densities of sex-patterned SNPs, as well as elevated number of ancestral copy number variants in this region when compared to the rest of the genome, but the pattern of differentiation along LG1 differs between species. The number of sex-patterned SNPs shared by the two species is small, but larger than expected by chance, suggesting that a novel Y-chromosome arose just before the divergence of the two species. We identified a shared sex-patterned SNP that alters a Gata4 binding site near Wilms tumor protein that might be responsible for sex-determination.
conclusionsShared sex-patterned SNPs, insertions and deletions suggest an ancestral sex-determination system that is common to both S. melanotheron and O. niloticus. Functional analyses are needed to evaluate shared SNPs near candidate genes that might play a role in sex-determination of these species. Interspecific variation in the sex chromosomes of tilapia species provides an excellent model system for understanding the evolution of vertebrate sex chromosomes.
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