Evidence map›Paper›PMID 27756214›Full record

ArticleBMC immunology2016

Chitosan gel vaccine protects against tumour growth in an intracaecal mouse model of cancer by modulating systemic immune responses.

Andrew J Highton, Adam Girardin, Georgia M Bell, Sarah M Hook, Roslyn A Kemp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew J HightonDepartment of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Adam GirardinDepartment of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Georgia M BellDepartment of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Sarah M HookSchool of Pharmacy, University of Otago, Dunedin, New Zealand.
Roslyn A KempDepartment of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin, 9054, New Zealand. roslyn.kemp@otago.ac.nz.
University of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVaccination generating a robust memory population of CD8

methodsWe used an intracaecal mouse model of cancer to determine whether a protective immune response against a mucosal gut tumour could be generated using a systemic intervention. We investigated the generation of murine memory CD8

resultsFollowing vaccination with Gel + OVA, CD8

conclusionThese results indicate that subcutaneous vaccination with Gel + OVA generates a population of functional CD8

Indexed as

AnimalsAntigen PresentationCancer VaccinesCarcinogenesisCD8-Positive T-LymphocytesCecumCell Growth ProcessesChitosanCytotoxicity, ImmunologicDendritic CellsDisease Models, AnimalGelsHumansImmunity, HumoralImmunologic MemoryImmunotherapy, AdoptiveCancer VaccinesChitosanGelsCaecumColon cancerIFN-γT cellsTumourVaccination

Identifiers

PMID27756214
PMCPMC5069793
OpenAlexW2537432960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.