ArticleMolecular plant pathology2018
A thiadiazole reduces the virulence of Xanthomonas oryzae pv. oryzae by inhibiting the histidine utilization pathway and quorum sensing.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 44 citations in OpenAlex.
- Transcriptomic response of Xanthomonas campestris during xanthan gum production to glutamate concentration.Scientific reports · 2026Article
- Interfering Transposable Elements: ISXoo15 Transposase as a First-in-Class Antibacterial Target Against Xanthomonas oryzae pv. oryzae.Molecular plant pathology · 2025Article
- Screening and Validation of Reference Genes for Normalization of qRT-PCR in Rice BLB PathogenGenes · 2025Article
- Copper-streptocycline application modulates pomegranate (Frontiers in plant science · 2025Article
- Metabolic Flux Analysis ofInternational journal of molecular sciences · 2024Article
- On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective.Frontiers in microbiology · 2023Review
- Evaluation of the Abilities of Three Kinds of Copper-Based Nanoparticles to Control Kiwifruit Bacterial Canker.Antibiotics (Basel, Switzerland) · 2022Article
- Antibacterial activity of peptaibols fromFrontiers in microbiology · 2022Article
- Evaluating the Antibacterial Activity and Mode of Action of Thymol-Loaded Chitosan Nanoparticles Against Plant Bacterial PathogenFrontiers in microbiology · 2021Article
- Antibacterial and biofilm inhibition activity of biofabricated silver nanoparticles against Xanthomonas oryzae pv. oryzae causing blight disease of rice instigates disease suppression.World journal of microbiology & biotechnology · 2020Article
- Global Regulator PhoP is Necessary for Motility, Biofilm Formation, Exoenzyme Production and Virulence ofGenes · 2019Article
- The Commonly Used Bactericide Bismerthiazol Promotes Rice Defenses against Herbivores.International journal of molecular sciences · 2018Article
- Niclosamide Blocks Rice Leaf Blight by Inhibiting Biofilm Formation ofFrontiers in plant science · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thiazole, isothiazole, thiadiazole and their derivatives are widely thought to induce host defences against plant pathogens. In this article, we report that bismerthiazol, a thiadiazole molecule, reduces disease by inhibiting the histidine utilization (Hut) pathway and quorum sensing (QS). Bismerthiazol provides excellent control of bacterial rice leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo), but does not greatly inhibit Xoo growth in vitro. According to RNA-sequencing analysis, the transcription of the Hut pathway genes of Xoo ZJ173 was inhibited after 4.5 and 9.0 h of bismerthiazol treatment. Functional studies of hutG and hutU indicated that the Hut pathway had little effect on the growth and bismerthiazol sensitivity of Xoo in vitro, but significantly reduced the aggregation of Xoo cells. Deletion mutants of hutG or hutU were more motile, produced less biofilm and were less virulent than the wild-type, indicating that the Hut pathway is involved in QS and contributes to virulence. The overexpression of the hutG-U operons in ZJ173 reduced Xoo control by bismerthiazol. Bismerthiazol did not inhibit the transcription of Hut pathway genes, QS or virulence of the bismerthiazol-resistant strain 2-1-1. The results indicate that bismerthiazol reduces Xoo virulence by inhibiting the Hut pathway and QS.
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