Evidence map›Paper›PMID 27756046›Full record

Trial reportJournal of affective disorders2017

Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders.

Danella Hafeman, Genna Bebko, Michele A Bertocci, Jay C Fournier, Henry W Chase, Lisa Bonar, Susan B Perlman, Michael Travis, Mary Kay Gill, Vaibhav A Diwadkar and 12 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Danella HafemanPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Genna BebkoPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Michele A BertocciPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Jay C FournierPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Henry W ChasePsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Lisa BonarPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Susan B PerlmanPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Michael TravisPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Mary Kay GillPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Vaibhav A DiwadkarPsychiatry and Behavioral Neuroscience, Wayne State University, USA.
Jeffrey L SunshineUniversity Hospitals Case Medical Center/Case Western Reserve University, USA.
Scott K HollandCincinnati Children's Hospital Medical Center, University of Cincinnati, USA.
Robert A KowatchThe Research Institute at Nationwide Children's Hospital, USA.
Boris BirmaherPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
David AxelsonPsychiatry and Behavioral Health, Ohio State University, USA.
Sarah M HorwitzChild Psychiatry, New York University School of Medicine, USA.
L Eugene ArnoldPsychiatry and Behavioral Health, Ohio State University, USA.
Mary A FristadPsychiatry and Behavioral Health, Ohio State University, USA.
Thomas W FrazierCleveland Clinic, Center for Pediatric Behavioral Health, USA.
Eric A YoungstromPsychology, University of North Carolina at Chapel Hill, USA.
Robert L FindlingUniversity Hospitals Case Medical Center/Case Western Reserve University, USA; Psychiatry, Johns Hopkins University, USA.
Mary L PhillipsPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA; Psychological Medicine, Cardiff University, United Kingdom.

Funding

Longitudinal Assessment of Manic SymptomsR01MH073967 · NIMH · JOHNS HOPKINS UNIVERSITY · PI FINDLING, ROBERT L · 2005 to 2016
$11.4M
CLINICAL RESEARCH TRAINING IN CHILD PSYCHIATRYT32MH018951 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TINA R GOLDSTEIN · 1990 to 2026
$9.7M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073953 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2005 to 2016
$8.7M
Training for Transformative Discovery in PsychiatryT32MH016804 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2025
$6.2M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073816 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI HOLLAND, SCOTT K. · 2005 to 2016
$5.9M
Longitudinal Assessment of Manic Symptoms (LAMS) StudyR01MH073801 · NIMH · OHIO STATE UNIVERSITY · PI FRISTAD, MARY A · 2005 to 2016
$5.9M
Neural Markers of Individual Difference in Emotion Regulation in Depressed AdultsK23MH097889 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOURNIER, JAY C · 2013 to 2017
$786k
NIMH NIH HHS K23 MH097889NIMH NIH HHS R01 MH073801NIMH NIH HHS R01 MH073816NIMH NIH HHS R01 MH073953NIMH NIH HHS R01 MH073967NIMH NIH HHS T32 MH016804NIMH NIH HHS T32 MH018951
6 · The paper itself

Abstract

objectiveBoth bipolar spectrum disorders (BPSD) and attention deficit hyperactivity disorder (ADHD) present with emotion-regulation deficits, but require different clinical management. We examined how the neurobiological underpinnings of emotion regulation might differentiate youth with BPSD versus ADHD (and healthy controls, HCs), specifically assessing functional connectivity (FxC) of amygdala-prefrontal circuitry during an implicit emotion processing task.

methodsWe scanned a subset of the Longitudinal Assessment of Manic Symptoms (LAMS) sample, a clinically recruited cohort with elevated behavioral and emotional dysregulation, and age/sex-ratio matched HCs. Our sample consisted of 22 youth with BPSD, 30 youth with ADHD/no BPSD, and 26 HCs. We used generalized psychophysiological interaction (gPPI) to calculate group differences to emerging emotional faces vs. morphing shapes in FxC between bilateral amygdala and ventral prefrontal cortex/anterior cingulate cortex.

resultsFxC between amygdala and left ventrolateral prefrontal cortex (VLPFC) in response to emotions vs. shapes differed by group (p=.05): while BPSD showed positive FxC (emotions>shapes), HC and ADHD showed inverse FxC (emotions<shapes). A group x emotion interaction was found in amygdala-subgenual cingulate FxC (p=.025), explained by differences in FxC in response to negative emotions. While BPSD showed positive FxC, HC showed inverse FxC; ADHD were intermediate. Amygdala-subgenual FxC was also positively associated with depressive symptoms and stimulant medication. LIMITATIONS: Co-morbidity and relatively small sample size.

conclusionsYouth with BPSD showed abnormally positive FxC between amygdala and regions in the ventral prefrontal cortex during emotion processing. In particular, the amygdala-VLPFC finding was specific to BPSD, and not influenced by other diagnoses or medications.

Indexed as

Magnetic Resonance ImagingAdolescentAmygdalaAttention Deficit Disorder with HyperactivityBipolar DisorderCase-Control StudiesChildDiagnosis, DifferentialEmotionsFacial ExpressionFemaleGyrus CinguliHumansLongitudinal StudiesMalePrefrontal CortexBipolar disorderfMRIImplicit emotion processingNeuroimaging

Identifiers

PMID27756046
PMCPMC5154789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.