Evidence map›Paper›PMID 27755986›Full record

ReviewNuclear medicine and biology2017

Tactics for preclinical validation of receptor-binding radiotracers.

Susan Z Lever, Kuo-Hsien Fan, John R Lever

Abstract readReview
In one paragraph

Review in Nuclear medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. The [18F] F-PSMA Probe: Chemical Perspectives.Current medicinal chemistry · 2025
    Review
  2. Evaluation of [Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Design, synthesis and evaluation ofNuclear medicine and biology · 2019
    Article
  9. Article
  10. Exploring the Metabolism of (+)-[Molecules (Basel, Switzerland) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Susan Z LeverDepartment of Chemistry, University of Missouri, Columbia, MO, USA; University of Missouri Research Reactor Center, Columbia, MO, USA. Electronic address: levers@missouri.edu.
Kuo-Hsien FanDepartment of Chemistry, University of Missouri, Columbia, MO, USA.
John R LeverDepartment of Radiology, University of Missouri, Columbia, MO, USA; Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, USA. Electronic address: leverj@health.missouri.edu.

Funding

Development of Anti-Cocaine MedicationsRC1DA028477 · NIDA · UNIVERSITY OF MISSOURI-COLUMBIA · PI LEVER, JOHN RILEY · 2009 to 2010
$679k
Radioligands for Sigma-2 Receptor Studies in the CNS by PETR21DA039818 · NIDA · UNIVERSITY OF MISSOURI-COLUMBIA · PI LEVER, SUSAN Z · 2015 to 2017
$638k
NIDA NIH HHS R21 DA039818NIDA NIH HHS RC1 DA028477
6 · The paper itself

Abstract

introductionAspects of radiopharmaceutical development are illustrated through preclinical studies of [

methodsSyntheses of E-IA-BF-PE-PIPZE and [

resultsE-IA-BF-PE-PIPZE exhibited high affinity and selectivity for σ

conclusionsSubstitution of dihydrobenzofuranylethyl for dimethoxyphenethyl increased radioligand affinity for σ

Indexed as

AnimalsRadioactive TracersRadiopharmaceuticalsReceptors, sigmaReproducibility of ResultsRadioactive TracersRadiopharmaceuticalsReceptors, sigmaImagingRadiopharmaceuticalRadiopharmacologyRadiotracerSigma receptorValidation

Identifiers

PMID27755986
PMCPMC5161541

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.