ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
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77citing papers in PubMed, 3 pooled it
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Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Blood-based biomarkers for Alzheimer's disease in Down syndrome: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Plasma amyloid and tau as dementia biomarkers in Down syndrome: Systematic review and meta-analyses.Developmental neurobiology · 2019Pooled it
- Blood-based biomarkers for Down syndrome and Alzheimer's disease: A systematic review.Developmental neurobiology · 2019Pooled it
- Growth Hormone-Releasing Hormone Modulation of Neuronal Exosome Biomarkers in Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2018Trial
- Extracellular Vesicles in Alzheimer's Disease: Mechanisms, Biomarkers, and Therapeutic Engineering.International journal of molecular sciences · 2026Review
- Proteome Signature of Alzheimer-Like Phenotypes in Frontal Cortices From Young and Old Individuals With Down Syndrome.Molecular neurobiology · 2025Article
- Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: A decade of discovery.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Extracellular vesicle-based point-of-care testing for diagnosis and monitoring of Alzheimer's disease.Microsystems & nanoengineering · 2025Article
- Nerve growth factor precursor alterations in neuron-derived extracellular vesicles from individuals with Down syndrome along the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Combination of Aβ40, Aβ42, and Tau Plasma Levels to Distinguish Amyloid-PET Positive Alzheimer Patients from Normal Controls.Experimental neurobiology · 2025Article
- Vesicular trafficking and cell-cell communication in neurodevelopment and neurodegeneration.Frontiers in cell and developmental biology · 2025Review
- Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases.Frontiers in immunology · 2025Review
- Potential Mechanisms of Tunneling Nanotube Formation and Their Role in Pathology Spread in Alzheimer's Disease and Other Proteinopathies.International journal of molecular sciences · 2024Review
- Nanoscale flow cytometry-based quantification of blood-based extracellular vesicle biomarkers distinguishes MCI and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Down Syndrome Biobank Consortium: A perspective.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder.Genes & diseases · 2024Article
- The Role of Tau Pathology in Alzheimer's Disease and Down Syndrome.Journal of clinical medicine · 2024Review
- Exosomes: new targets for understanding axon guidance in the developing central nervous system.Frontiers in cell and developmental biology · 2024Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors.
Eric D HamlettDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
Edward J GoetzlGeriatric Research Center of the Jewish Home of San Francisco, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA.
Aurélie LedreuxDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
Vitaly VasilevkoUniversity of California, Irvine Institute for Memory Impairment and Neurological Disorders, Irvine, CA, USA.
Heather A BogerDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Center on Aging, Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Angela LaRosaDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
David ClarkDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Steven L CarrollDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
María Carmona-IraguiMemory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau, Barcelona, Spain; Down Medical Center, Fundacío Catalana Síndrome de Down, Barcelona, Spain.
Juan ForteaMemory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau, Barcelona, Spain; Down Medical Center, Fundacío Catalana Síndrome de Down, Barcelona, Spain.
Elliott J MufsonBarrow Neurological Institute, Department of Neurobiology, Phoenix, AZ, USA.
Marwan SabbaghBarrow Neurological Institute, Department of Neurobiology, Phoenix, AZ, USA.
Abdul H MohammedDepartment of Psychology, Linnaeus University, Växjo, Sweden; Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.
Dean HartleyAlzheimer's Association, Chicago, IL, USA.
Eric DoranDepartment of Pediatrics, School of Medicine, University of California, Irvine, Orange, CA, USA.
Ira T LottDepartment of Pediatrics, School of Medicine, University of California, Irvine, Orange, CA, USA.
Ann-Charlotte GranholmDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; The Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA; The Center on Aging, Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden. Electronic address: Lotta.granholm-bentley@DU.edu.
Funding
TAU, AB, SYNUCLEIN AND NITRATIVE/OXIDATIVE DAMAGE IN MCIP01AG014449 · NIA · UNIVERSITY OF PITTSBURGH · PI COUNTS, SCOTT E · 1997 to 2024
$39.7MUC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0MUniversity of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1MBiomarkers of Alzheimer's Disease in Adults with Down SyndromeU01AG051412 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOTT, IRA T., SCHUPF, NICOLE · 2015 to 2019
$26.3MInstitute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1MPredicting Cognitive Decline in Adults with Down SyndromeR01HD065160 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI LOTT, IRA T. · 2009 to 2013
$2.3MAlzheimer's Disease in Down Syndrome: Antioxidant TrialR01AG021912 · NIA · UNIVERSITY OF CALIFORNIA IRVINE · PI LOTT, IRA T · 2003 to 2005
$1.1MBiological Correlates of Alzheimer in Down Syndrome.R21AG056974 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER · 2017 to 2018
$414kNCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NIA NIH HHS P01 AG014449NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG021912NIA NIH HHS R21 AG056974NIA NIH HHS U01 AG051412NICHD NIH HHS R01 HD065160
Abstract
introductionIndividuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD neuropathology would be valuable, as non-AD intellectual disabilities of DS and AD dementia overlap clinically. We hypothesized that elevations of amyloid β (Aβ) peptides and phosphorylated-tau in neuronal exosomes may document preclinical AD.
methodsAD neuropathogenic proteins Aβ
resultsNeuronal exosome levels of Aβ DISCUSSION: These early increases in Aβ
Indexed as
AdolescentAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersDown SyndromeExosomesFemaleHumansMaleMiddle AgedPeptide Fragmentstau ProteinsYoung AdultAmyloid beta-PeptidesBiomarkersPeptide Fragmentstau ProteinsAlzheimer's diseaseAmyloid-βBlood biomarkersDown syndromeHyperphosphorylated tauIntellectual disabilityNeuronal exosomes
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