Evidence map›Paper›PMID 27755915›Full record

ArticleAmerican journal of respiratory cell and molecular biology2017

Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury.

Khalil Bdeir, Kandace Gollomp, Marta Stasiak, Junjie Mei, Izabela Papiewska-Pajak, Guohua Zhao, G Scott Worthen, Douglas B Cines, Mortimer Poncz, M Anna Kowalska

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 70 citations in OpenAlex.

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  9. A narrative review of chemokine receptors CXCR1 and CXCR2 and their role in acute respiratory distress syndrome.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  10. Article
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  13. Albumin-Bilirubin Score: A Novel Mortality Predictor in Valvular Surgery.Brazilian journal of cardiovascular surgery · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Khalil BdeirDepartments of 1 Pathology and Laboratory Medicine and.
Kandace GollompDivisions of 2 Hematology and.
Marta Stasiak3 Department of Cytobiology and Proteomics, Medical University of Lodz, Lodz, Poland; and.
Junjie Mei4 Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Izabela Papiewska-Pajak5 Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Guohua ZhaoDivisions of 2 Hematology and.
G Scott Worthen6 Pediatrics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania.
Douglas B CinesDepartments of 1 Pathology and Laboratory Medicine and.
Mortimer Poncz6 Pediatrics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, Pennsylvania.
M Anna KowalskaDivisions of 2 Hematology and.
Children's Hospital of Philadelphia · USHematology Oncology Associates · USInstitute for Medical Biology · PLMedical University of Lodz · PLUniversity of Pennsylvania · US

Funding

Protein CoreP01HL110860 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI RAUOVA, LUBICA · 2012 to 2016
$11.4M
RED CELL HEMOGLOBIN RESEARCH TRAINING PROGRAMT32HL007150 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI STELLA T CHOU, Mortimer Poncz · 1985 to 2026
$7.4M
CXC Chemokines and Regulation of GranulopoiesisR01AI099479 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI WORTHEN, GEORGE SCOTT · 2013 to 2017
$2.1M
Prevention and management of perioperative pulmonary embolismR01HL116916 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CINES, DOUGLAS BROCK, MUZYKANTOV, VLADIMIR R · 2013 to 2016
$1.6M
Developmental endothelial locus-1 (Del-1) is a hemostatic factor in thrombotic strokeR21NS091793 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BDEIR, KHALIL · 2015 to 2016
$440k
Antiatherogenic effects of neutrophil alpha defensinsR21AI102177 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BDEIR, KHALIL · 2012 to 2013
$428k
NHLBI NIH HHS P01 HL110860NHLBI NIH HHS R01 HL116916NHLBI NIH HHS T32 HL007150NIAID NIH HHS R01 AI099479NIAID NIH HHS R21 AI102177NINDS NIH HHS R21 NS091793
6 · The paper itself

Abstract

Platelets and neutrophils contribute to the development of acute lung injury (ALI). However, the mechanism by which platelets make this contribution is incompletely understood. We investigated whether the two most abundant platelet chemokines, CXCL7, which induces neutrophil chemotaxis and activation, and CXCL4, which does neither, mediate ALI through complementary pathogenic pathways. To examine the role of platelet-derived chemokines in the pathogenesis of ALI using Cxcl7

Indexed as

Acute Lung InjuryAnimalsBlood PlateletsCapillary PermeabilityChemokines, CXCHumansLungMice, TransgenicPlatelet Factor 4Chemokines, CXCCxcl7 protein, mousePlatelet Factor 4acute lung injurychemokinesplatelets

Identifiers

PMID27755915
PMCPMC5455412
OpenAlexW2533664315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.