Evidence map›Paper›PMID 27755372›Full record

Observational studyRetina (Philadelphia, Pa.)2017

ULTRA-WIDE-FIELD FUNDUS AUTOFLUORESCENCE FINDINGS IN PATIENTS WITH ACUTE ZONAL OCCULT OUTER RETINOPATHY.

Amde Selassie Shifera, Mark E Pennesi, Paul Yang, Phoebe Lin

Abstract readObservational Study
In one paragraph

Observational study in Retina (Philadelphia, Pa.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Topographic patterns of retinal lesions in multiple evanescent white dot syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Clinic-based ultra-wide field retinal imaging in a pediatric population.International journal of retina and vitreous · 2019
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amde Selassie Shifera*Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, MD; and †the Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Mark E Pennesi
Paul Yang
Phoebe Lin
Johns Hopkins University · US

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CATHERINE W MORGANS · 1995 to 2026
$19.4M
Neuroprotective Mechanisms of Inosine Monophosphate Dehydrogenase Inhibitors in Retinitis PigmentosaK08EY026650 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI YANG, PAUL · 2016 to 2020
$1.1M
The effect of the microbiome on the development and severity of uveitisK08EY022948 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LIN, PHOEBE · 2013 to 2017
$1.0M
Serotonin Receptor Modulation of Neurotrophic Factors in the RetinaK08EY021186 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI PENNESI, MARK E · 2011 to 2015
$824k
NEI NIH HHS K08 EY021186NEI NIH HHS K08 EY022948NEI NIH HHS K08 EY026650NEI NIH HHS P30 EY010572
6 · The paper itself

Abstract

purposeTo determine whether ultra-wide-field fundus autofluorescence (UWFFAF) findings in acute zonal occult outer retinopathy correlated well with perimetry, optical coherence tomography, and electroretinography findings.

methodsRetrospective observational study on 16 eyes of 10 subjects with AZOOR seen at a single referral center from October 2012 to March 2015 who had UWFFAF performed. Chi-square analysis was performed to compare categorical variables, and Mann-Whitney U test used for comparisons of nonparametric continuous variables.

resultsAll eyes examined within 3 months of symptom onset (five of the five eyes) had diffusely hyperautofluorescent areas on UWFFAF. The remaining eyes contained hypoautofluorescent lesions with hyperautofluorescent borders. In 11/16 (68.8%) eyes, UWFFAF showed the full extent of lesions that would not have been possible with standard fundus autofluorescence centered on the fovea. There were 3 patterns of spread: centrifugal spread (7/16, 43.8%), centripetal spread (5/16, 31.3%), and centrifugal + centripetal spread (4/16, 25.0%). The UWFFAF lesions corresponded well with perimetric, optical coherence tomography, and electroretinography abnormalities.

conclusionThe UWFFAF along with optical coherence tomography can be useful in the evaluation and monitoring of acute zonal occult outer retinopathy patients.

Indexed as

Visual FieldsAdolescentAdultAgedElectroretinographyFemaleFluorescein AngiographyFovea CentralisFundus OculiHumansMaleMiddle AgedRetrospective StudiesScotomaTomography, Optical CoherenceVisual Acuity

Identifiers

PMID27755372
PMCPMC5393961
OpenAlexW2538701658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.