Evidence map›Paper›PMID 27754869›Full record

ArticleThe Journal of biological chemistry2016

The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex.

Stefanie Memmer, Sandra Weil, Steffen Beyer, Tobias Zöller, Eike Peters, Jessica Hartmann, Alexander Steinle, Joachim Koch

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  2. Article
  3. Review
  4. Single-cell profiling identifies a CD8Nature communications · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Stefanie MemmerFrom the Institute of Medical Microbiology and Hygiene, University of Mainz Medical Center, 55131 Mainz, Germany.
Sandra WeilFrom the Institute of Medical Microbiology and Hygiene, University of Mainz Medical Center, 55131 Mainz, Germany.
Steffen Beyerthe Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt am Main, Germany.
Tobias Zöllerthe Institute for Molecular Medicine, Goethe-University Frankfurt am Main, 60528 Frankfurt am Main, Germany.
Eike Petersthe Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt am Main, Germany.
Jessica Hartmannthe Division of Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany, and.
Alexander Steinlethe Institute for Molecular Medicine, Goethe-University Frankfurt am Main, 60528 Frankfurt am Main, Germany.
Joachim KochFrom the Institute of Medical Microbiology and Hygiene, University of Mainz Medical Center, 55131 Mainz, Germany, joachim.koch@uni-mainz.de.
Georg Speyer Haus · DEGoethe University Frankfurt · DEJohannes Gutenberg University Mainz · DEPaul Ehrlich Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The natural cytotoxicity receptor (NCR) NKp30 (CD337) is a key player for NK cell immunosurveillance of infections and cancer. The molecular details of ligand recognition and its connection to CD3ζ signaling remain unsolved. Here, we show that the stalk domain (

Indexed as

AnimalsCD3 ComplexCell MembraneHeLa CellsHumansMiceNatural Cytotoxicity Triggering Receptor 1Natural Cytotoxicity Triggering Receptor 3Protein DomainsSignal TransductionCD3 ComplexCD3E protein, humanNatural Cytotoxicity Triggering Receptor 1Natural Cytotoxicity Triggering Receptor 3NCR1 protein, humanNCR3 protein, humancell signalingcell surface receptormembrane proteinnatural killer cells (NK cells)protein-protein interactionreceptor modificationreceptor regulation

Identifiers

PMID27754869
PMCPMC5207244
OpenAlexW2538521083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.