Evidence map›Paper›PMID 27754615›Full record

ArticleCytometry. Part A : the journal of the International Society for Analytical Cytology2016

Consistent quantitative gene product expression: #3. Invariance with age.

Michael R Loken, Andrew P Voigt, Lisa Eidenschink Brodersen, Wayne Fritschle, Andrew J Menssen, Denise A Wells

Open access · bronzeAbstract read
In one paragraph

Article in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
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  7. Consistent quantitative gene product expression: #2. Antigen intensities on bone marrow cells are invariant between individuals.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael R LokenHematoLogics, Inc, Seattle, Washington.
Andrew P VoigtHematoLogics, Inc, Seattle, Washington.
Lisa Eidenschink BrodersenHematoLogics, Inc, Seattle, Washington.
Wayne FritschleHematoLogics, Inc, Seattle, Washington.
Andrew J MenssenHematoLogics, Inc, Seattle, Washington.
Denise A WellsHematoLogics, Inc, Seattle, Washington.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The quantitative expression of cell surface antigens and light scattering properties of five cellular reference populations in stressed bone marrow specimens were compared between pediatric and adult patients treated for acute myeloid leukemia (AML). The mean intensity of each antigen as well as the within patient and between patient variability showed striking consistency between the two different age groups. The only difference between the groups of specimens was the proportion of progenitor cells in the adult cohort averaged less than three times the proportion in the pediatric cohort. These data show that the amounts of gene products expressed on bone marrow cells are invariant with age. © 2016 The Authors. Cytometry Part A Published by Wiley Periodicals, Inc. on behalf of ISAC.

Indexed as

Support Vector MachineTranscriptomeAdultAgedFlow CytometryHematopoietic Stem CellsHumansLeukemia, Myeloid, AcuteMiddle Agedadultbone marrow aspiratesflow cytometryquantitative antigen expressionsupport vector machines

Identifiers

PMID27754615
PMCPMC5132053
OpenAlexW2538398743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.