Evidence map›Paper›PMID 27754503›Full record

ArticleLab on a chip2016

Acoustofluidic coating of particles and cells.

Bugra Ayan, Adem Ozcelik, Hunter Bachman, Shi-Yang Tang, Yuliang Xie, Mengxi Wu, Peng Li, Tony Jun Huang

Abstract read
In one paragraph

Article in Lab on a chip, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Acoustic Actuation ofJournal of micromechanics and microengineering : structures, devices, and systems · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bugra AyanDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Adem OzcelikDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA. tony.huang@duke.edu.
Hunter BachmanDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA. tony.huang@duke.edu.
Shi-Yang TangDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Yuliang XieDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Mengxi WuDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA. tony.huang@duke.edu.
Peng LiDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Tony Jun HuangDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA and Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA. tony.huang@duke.edu.

Funding

Standing Surface Acoustic Wave Based Cell Sorters for Maintaining Cell IntegrityR01GM112048 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2017
$1.1M
Validation of acoustic tweezers for single-cell analyses of purine metabolismR33EB019785 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2016
$1.1M
NIBIB NIH HHS R33 EB019785NIGMS NIH HHS R01 GM112048
6 · The paper itself

Abstract

On-chip microparticle and cell coating technologies enable a myriad of applications in chemistry, engineering, and medicine. Current microfluidic coating technologies often rely on magnetic labeling and concurrent deflection of particles across laminar streams of chemicals. Herein, we introduce an acoustofluidic approach for microparticle and cell coating by implementing tilted-angle standing surface acoustic waves (taSSAWs) into microchannels with multiple inlets. The primary acoustic radiation force generated by the taSSAW field was exploited in order to migrate the particles across the microchannel through multiple laminar streams, which contained the buffer and coating chemicals. We demonstrate effective coating of polystyrene microparticles and HeLa cells without the need for magnetic labelling. We characterized the coated particles and HeLa cells with fluorescence microscopy and scanning electron microscopy. Our acoustofluidic-based particle and cell coating method is label-free, biocompatible, and simple. It can be useful in the on-chip manufacturing of many functional particles and cells.

Indexed as

AcousticsLab-On-A-Chip DevicesEquipment DesignHeLa CellsHumansMicrospheres

Identifiers

PMID27754503
PMCPMC5465870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.