Evidence map›Paper›PMID 27754485›Full record

ArticleTranslational psychiatry2016

Perinatal psychiatric episodes: a population-based study on treatment incidence and prevalence.

T Munk-Olsen, M L Maegbaek, B M Johannsen, X Liu, L M Howard, A di Florio, V Bergink, S Meltzer-Brody

Abstract read
In one paragraph

Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Brexanolone, zuranolone and related neurosteroid GABAThe Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Antidepressant treatment for postnatal depression.The Cochrane database of systematic reviews · 2021
    Pooled it
  6. Article
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  9. Review
  10. Article
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  13. Sibling Psychiatric Disorders and Risk of Postpartum Psychosis.medRxiv : the preprint server for health sciences · 2025
    Article
  14. Article
  15. Review
  16. Familial Risk of Postpartum Psychosis.The American journal of psychiatry · 2025
    Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T Munk-OlsenDepartment of Economics and Business Economics, National Center for Register-based Research, Aarhus University, Aarhus, Denmark.
M L MaegbaekDepartment of Economics and Business Economics, National Center for Register-based Research, Aarhus University, Aarhus, Denmark.
B M JohannsenDepartment of Economics and Business Economics, National Center for Register-based Research, Aarhus University, Aarhus, Denmark.
X LiuDepartment of Economics and Business Economics, National Center for Register-based Research, Aarhus University, Aarhus, Denmark.
L M HowardHealth Service and Population Research Department, Institute of Psychiatry, King's College London, London, UK.
A di FlorioDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
V BerginkDepartment of Economics and Business Economics, National Center for Register-based Research, Aarhus University, Aarhus, Denmark.
S Meltzer-BrodyUNC Center for Women's Mood Disorder, Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Epidemiological and Genetic Predictors of Postpartum Mood DisordersR01MH104468 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MELTZER-BRODY, SAMANTHA ERIKA · 2014 to 2017
$2.6M
NIMH NIH HHS R01 MH104468
6 · The paper itself

Abstract

Perinatal psychiatric episodes comprise various disorders and symptom severity, which are diagnosed and treated in multiple treatment settings. To date, no studies have quantified the incidence and prevalence of perinatal psychiatric episodes treated in primary and secondary care, which we aimed to do in the present study. We designed a descriptive prospective study and included information from Danish population registers to study first-time ever and recurrent psychiatric episodes during the perinatal period, including treatment at psychiatric facilities and general practitioners (GPs). This was done for all women who had records of one or more singleton births from 1998 until 2012. In total, we had information on 822 439 children born to 491 242 unique mothers. Results showed first-time psychiatric episodes treated at inpatient facilities were rare during pregnancy, but increased significantly shortly following childbirth (0.02 vs 0.25 per 1000 births). In comparison, first-time psychiatric episodes treated at outpatient facilities were more common, and showed little variation across pregnancy and postpartum. For every single birth resulting in postpartum episodes treated at inpatient psychiatric facilities, 2.5 births were followed by an episode treated at outpatient psychiatric facility and 12 births by GP-provided pharmacological treatment. We interpret our results the following way: treated severe and moderate psychiatric disorders have different risk patterns in relation to pregnancy and childbirth, which suggests differences in the underlying etiology. We further speculate varying treatment incidence and prevalence in pregnancy vs postpartum may indicate that the current Diagnostic and Statistical Manual of Mental Disorders-5 peripartum specifier not adequately describes at-risk periods across moderate and severe perinatal psychiatric episodes.

Indexed as

AdultAmbulatory CareCross-Sectional StudiesDenmarkFemaleGeneral PracticeHospitals, PsychiatricHumansIncidenceInfant, NewbornMental DisordersPatient AdmissionPregnancyPregnancy ComplicationsProspective StudiesPuerperal Disorders

Identifiers

PMID27754485
PMCPMC5315550

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.