Evidence map›Paper›PMID 27754357›Full record

ReviewInternational journal of molecular sciences2016

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions.

Caterina Catalanotto, Carlo Cogoni, Giuseppe Zardo

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05726695 (The Use of miRNA Detection for Diagnostics of Cardiovascular Diseases), which is not on this map. Cited by 658 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
658citing papers in PubMed, 7 pooled it
33.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05726695 unknown statusnot on this mapstarted 2018, after this paper: background citation

The Use of miRNA Detection for Diagnostics of Cardiovascular Diseases

TypeobservationalSponsorUniversity Hospital OstravaRan2018 to 2023Enrolled200ConditionsHeart Failure, Heart Dilation, Left Ventricular HypertrophyArmsmicroRNA test, Heart ultrasound examination
3 · Its place in the literature

Who cites it

658 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,204 citations in OpenAlex.

  1. Pooled it
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  4. Recent Advances in Biomonitoring of Gas Station Workers: A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2024
    Pooled it
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  8. Review
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  17. Regulation of humeral fracture healing by miR-21 through SMAD7-mediated activation of Wnt/β-catenin signaling.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
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598 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Caterina CatalanottoDepartment of Cellular Biotechnologies and Hematology, University of Rome Sapienza, Rome 00179, Italy. caterina.catalanotto@uniroma1.it.
Carlo CogoniDepartment of Cellular Biotechnologies and Hematology, University of Rome Sapienza, Rome 00179, Italy. carlo.cogoni@uniroma1.it.
Giuseppe ZardoDepartment of Cellular Biotechnologies and Hematology, University of Rome Sapienza, Rome 00179, Italy. giuseppe.zardo@uniroma1.it.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the discovery and classification of several types of ncRNAs. Based on their precursor structures, biogenesis pathways and modes of action, ncRNAs are classified as small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs), promoter associate RNAs (pRNAs), small nucleolar RNAs (snoRNAs) and sno-derived RNAs. Among these, miRNAs appear as important cytoplasmic regulators of gene expression. miRNAs act as post-transcriptional regulators of their messenger RNA (mRNA) targets via mRNA degradation and/or translational repression. However, it is becoming evident that miRNAs also have specific nuclear functions. Among these, the most studied and debated activity is the miRNA-guided transcriptional control of gene expression. Although available data detail quite precisely the effectors of this activity, the mechanisms by which miRNAs identify their gene targets to control transcription are still a matter of debate. Here, we focus on nuclear functions of miRNAs and on alternative mechanisms of target recognition, at the promoter lavel, by miRNAs in carrying out transcriptional gene silencing.

Indexed as

Gene Expression RegulationAlternative SplicingAnimalsCell NucleolusCytoplasmHumansMicroRNAsRNA TransportTranscriptomeMicroRNAsepigeneticsmicroRNAmiRNA inducing silencing complex (miRISC)nuclear functiontranscriptional control

Identifiers

PMID27754357
PMCPMC5085744
OpenAlexW2530597079

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.