Evidence map›Paper›PMID 27754355›Full record

ArticleToxins2016

Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells.

Laura Julia Starost, Sascha Karassek, Yasuteru Sano, Takashi Kanda, Kwang Sik Kim, Ulrich Dobrindt, Christian Rüter, Marcus Alexander Schmidt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Frontiers in cellular and infection microbiology · 2025
    Article
  2. International journal of molecular sciences · 2021
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Laura Julia StarostInstitute of Infectiology, Center of Molecular Biology of Inflammation, Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany. l_star02@uni-muenster.de.
Sascha KarassekInstitute of Infectiology, Center of Molecular Biology of Inflammation, Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany. sascha.karassek@hotmail.com.
Yasuteru SanoDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Ube City 755-8505, Japan. yasuteru@yamaguchi-u.ac.jp.
Takashi KandaDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Ube City 755-8505, Japan. tkanda@yamaguchi-u.ac.jp.
Kwang Sik KimPediatric Infectious Diseases Division, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. kwangkim@jhmi.edu.
Ulrich DobrindtInstitute of Hygiene, Microbial Genome Plasticity-Molecular Infection Biology, Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany. dobrindt@uni-muenster.de.
Christian RüterInstitute of Infectiology, Center of Molecular Biology of Inflammation, Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany. rueterc@uni-muenster.de.
Marcus Alexander SchmidtInstitute of Infectiology, Center of Molecular Biology of Inflammation, Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany. infekt@uni-muenster.de.
University of Münster · DEYamaguchi University · JPJohns Hopkins Medicine · US

Funding

Host factors and bacterial meningitisR01NS091102 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KIM, KWANG S · 2015 to 2019
$1.8M
E. coli penetration of the blood-brain barrierR21AI113273 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIM, KWANG S · 2016 to 2017
$446k
Bacterial penetration of the blood-brain barrierR21AI114925 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIM, KWANG S · 2015 to 2016
$446k
NIAID NIH HHS R21 AI113273NIAID NIH HHS R21 AI114925NINDS NIH HHS R01 NS091102
6 · The paper itself

Abstract

Pertussis toxin (PTx), the major virulence factor of the whooping cough-causing bacterial pathogen

Indexed as

Escherichia coliCell AdhesionCell LineCerebrumCytokinesEndothelial CellsHumansIntercellular Adhesion Molecule-1Meningitis, Escherichia coliMonocytesNF-kappa Bp38 Mitogen-Activated Protein KinasesPertussis ToxinPhosphorylationRNA, MessengerSignal TransductionCytokinesIntercellular Adhesion Molecule-1NF-kappa Bp38 Mitogen-Activated Protein KinasesPertussis ToxinRNA, MessengerSTAT3 Transcription Factorblood–brain barrierMAPK p38neonatal meningitis-causing E. coli K1-RS218NF-κBNMECpertussis toxin

Identifiers

PMID27754355
PMCPMC5086651
OpenAlexW2531273280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.