Evidence map›Paper›PMID 27753525›Full record

ArticleAutophagy2016

Autophagy-mediated catabolism of visual transduction proteins prevents retinal degeneration.

Jingyu Yao, Lin Jia, Kecia Feathers, Chengmao Lin, Naheed W Khan, Daniel J Klionsky, Thomas A Ferguson, David N Zacks

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 44 citations in OpenAlex.

  1. Autophagy in ocular diseases: from mechanisms to therapeutic potential.Frontiers in cell and developmental biology · 2026
    Review
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  14. Proteostasis in aging-associated ocular disease.Molecular aspects of medicine · 2022
    Review
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  16. Article
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jingyu Yaoa Department of Ophthalmology and Visual Sciences , University of Michigan , Ann Arbor , MI , USA.
Lin Jiaa Department of Ophthalmology and Visual Sciences , University of Michigan , Ann Arbor , MI , USA.
Kecia Feathersa Department of Ophthalmology and Visual Sciences , University of Michigan , Ann Arbor , MI , USA.
Chengmao Lina Department of Ophthalmology and Visual Sciences , University of Michigan , Ann Arbor , MI , USA.
Naheed W Khana Department of Ophthalmology and Visual Sciences , University of Michigan , Ann Arbor , MI , USA.
Daniel J Klionskyb Life Sciences Institute, University of Michigan , Ann Arbor , MI , USA.
Thomas A Fergusond Department of Ophthalmology and Visual Sciences , Washington University School of Medicine , St. Louis , MO , USA.
David N Zacksa Department of Ophthalmology and Visual Sciences , University of Michigan , Ann Arbor , MI , USA.
University of Michigan–Ann Arbor · US

Funding

ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEASTR01GM053396 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KLIONSKY, DANIEL J. · 1995 to 2018
$12.1M
Molecular Regulation of Photoreceptor Cell DeathR01EY020823 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABCOUWER, STEVEN F, ZACKS, DAVID N · 2010 to 2023
$5.0M
NEI NIH HHS R01 EY020823NIGMS NIH HHS R01 GM053396
6 · The paper itself

Abstract

Autophagy is a lysosomal degradation pathway critical to preventing the accumulation of cytotoxic proteins. Deletion of the essential autophagy gene Atg5 from the rod photoreceptors of the retina (atg5

Indexed as

AutophagyLight Signal TransductionProteolysisAnimalsAutophagosomesAutophagy-Related Protein 5Cell LineCrosses, GeneticEye ProteinsFemaleGreen Fluorescent ProteinsGTP-Binding Protein alpha SubunitsMaleMiceMice, KnockoutReproducibility of ResultsAtg5 protein, mouseAutophagy-Related Protein 5Eye ProteinsGnat1 protein, mouseGreen Fluorescent ProteinsGTP-Binding Protein alpha SubunitsTransducinautophagyphotoreceptorretinaretinal degenerationtransducin

Identifiers

PMID27753525
PMCPMC5173283
OpenAlexW2532287325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.