ArticleThe Laryngoscope2017
Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis.
Article in The Laryngoscope, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Procalcitonin as a Biomarker in Rhinosinusitis: A Systematic Review.American journal of rhinology & allergy · 2019Pooled it
- Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2018Pooled it
- Primary Ciliary Dyskinesia: A Clinical Review.Cells · 2024Review
- Very-Low-Level Viremia, Inflammatory Biomarkers, and Associated Baseline Variables: Three-Year Results of the Randomized TANGO Study.Open forum infectious diseases · 2024Article
- Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine.Children (Basel, Switzerland) · 2023Review
- Gas Monitoring in Human Frontal Sinuses-Stability Considerations and Gas Exchange Studies.Sensors (Basel, Switzerland) · 2021Article
- Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020.Current allergy and asthma reports · 2020Review
- Nasal nitric oxide is a useful biomarker for acute unilateral maxillary sinusitis in pediatric allergic rhinitis: A prospective observational cohort study.The World Allergy Organization journal · 2019Article
- Inflammatory Biomarkers During Bacterial Acute Rhinosinusitis.Current allergy and asthma reports · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo illuminate the pathophysiology of acute rhinosinusitis (ARS) with sequential monitoring of inflammatory biomarkers during an ARS episode and to clarify their diagnostic usability in bacterial ARS. STUDY
designInception cohort study with 50 conscripts with ARS.
methodsWe collected peripheral blood high-sensitive C-reactive protein (hs-CRP), white blood cell (WBC), procalcitonin, and nasal nitric oxide (nNO) counts at 2 to 3 and 9 to 10 days of symptoms during an ARS episode. We simultaneously gathered various clinical parameters and microbiological samples. Bacterial ARS was confirmed with a positive culture of sinus aspirate.
resultsReciprocal correlations and a significant change in biomarker levels between the two visits suggest that ARS involves a local and systemic inflammatory response that was strongest at 2 to 3 days. High-sensitive CRP and nNO reflected responses best (52% had increased CRP levels at 2-3 days; 66% had decreased nNO levels). White blood cell and procalcitonin counts rarely exceeded the reference range. Increased local and systemic inflammatory response were linked to multiple, adenoviral, or influenza A viral etiology or the detection of bacterial ARS. Local response correlated with imaging findings of wide paranasal sinus involvement and ostiomeatal complex occlusion. At 9 to 10 days, elevated (≥ 11 mg/L) and moderately elevated (≥ 49 mg/L) hs-CRP predicted bacterial ARS well (likelihood ratio [LR]+ 3.3 and LR+ 15.8, respectively), but the sensitivity for both findings remained low.
conclusionAcute rhinosinusitis (particularly bacterial ARS) involves a local and systemic inflammatory response that is strongest at the beginning of symptoms. Elevated hs-CRP supports the diagnosis of bacterial ARS. LEVEL OF EVIDENCE: 4. Laryngoscope, 2016 127:E55-E61, 2017.
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