Evidence map›Paper›PMID 27753095›Full record

ArticleThe Journal of physiology2017

Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells.

Jian Shi, Francesc Miralles, Lutz Birnbaumer, William A Large, Anthony P Albert

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Orai storeoperated CaChannels (Austin, Tex.) · 2025
    Review
  3. Article
  4. Review
  5. Store-operated calcium entry: Pivotal roles in renal physiology and pathophysiology.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  6. Proteins Interacting with STIM1 and Store-Operated CaProgress in molecular and subcellular biology · 2021
    Review
  7. Obligatory role for PKCδ in PIPThe Journal of physiology · 2020
    Article
  8. Article
  9. Review
  10. Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli.Laboratory investigation; a journal of technical methods and pathology · 2020
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Integration of CaOncogene · 2018
    Article
  18. Dual action of the GαScientific reports · 2018
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Jian ShiVascular Biology Research Centre, Molecular & Clinical Sciences Research Institute.
Francesc MirallesVascular Biology Research Centre, Molecular & Clinical Sciences Research Institute.
Lutz BirnbaumerNeurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
William A LargeVascular Biology Research Centre, Molecular & Clinical Sciences Research Institute.
Anthony P AlbertVascular Biology Research Centre, Molecular & Clinical Sciences Research Institute.ORCID 0000-0002-3596-9634
Pontificia Universidad Católica Argentina · ARSt George's, University of London · GB

Funding

Transmembrane Signaling Mechanisms Involving TRP ChannelsZ01ES101684 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$2.1M
Biotechnology and Biological Sciences Research Council BB/J007226/1Biotechnology and Biological Sciences Research Council BB/M018350/1NIEHS NIH HHS Z01 ES101684
6 · The paper itself

Abstract

key pointsDepletion of Ca ABSTRACT: In vascular smooth muscle cells (VSMCs), stimulation of canonical transient receptor potential channel 1 (TRPC1) protein-based store-operated channels (SOCs) mediates Ca

Indexed as

Calcium SignalingAnimalsCells, CulturedGTP-Binding Protein alpha SubunitsMuscle, Smooth, VascularMyocytes, Smooth MuscleProtein Kinase C betaRabbitsStromal Interaction Molecule 1TRPC Cation ChannelsGTP-Binding Protein alpha SubunitsProtein Kinase C betaStromal Interaction Molecule 1TRPC Cation ChannelsPLCSTIM1TRPCvascular smooth muscle

Identifiers

PMID27753095
PMCPMC5309361
OpenAlexW2559996517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.