ReviewCurrent topics in behavioral neurosciences
Neurotoxicology of Synthetic Cathinone Analogs.
Review in Current topics in behavioral neurosciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Neurotoxicity-Based Toxicometabolomics ofACS omega · 2025Article
- Clinical and Public Health Challenge of Handling Synthetic Cathinone and Cannabinoid Abuse in Pediatric Care: A Narrative Review.Pediatric reports · 2025Review
- Structure-Activity Relationship of Synthetic Cathinones: An Updated Review.ACS pharmacology & translational science · 2024Review
- Synthetic Cathinones: Epidemiology, Toxicity, Potential for Abuse, and Current Public Health Perspective.Brain sciences · 2024Review
- Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones.Neuropharmacology · 2024Article
- Effects of Prenatal Methcathinone Exposure on the Neurological Behavior of Adult Offspring.Current neuropharmacology · 2024Article
- Methamphetamine and Designer Stimulants Modulate Tonic Human Cerebrovascular Smooth Muscle Contractility: Relevance to Drug-Induced Neurovascular Stress.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
- Integrated Approach for Synthetic Cathinone Drug Prioritization and Risk Assessment: In Silico Approach and Sub-Chronic Studies inMolecules (Basel, Switzerland) · 2023Article
- Structure-Activity Relationship ofACS chemical neuroscience · 2023Article
- Sex differences in inflammatory cytokine levels following synthetic cathinone self-administration in rats.Neurotoxicology · 2022Article
- Problem-solving deficits in methcathinone use disorder.Psychopharmacology · 2021Article
- Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment.Neurotoxicity research · 2021Article
- Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Psychoactive Drugs-From Chemical Structure to Oxidative Stress Related to Dopaminergic Neurotransmission. A Review.Antioxidants (Basel, Switzerland) · 2021Review
- Effects of Mephedrone and Amphetamine Exposure during Adolescence on Spatial Memory in Adulthood: Behavioral and Neurochemical Analysis.International journal of molecular sciences · 2021Article
- Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Effects of Methcathinone Exposure during Prenatal and Lactational Periods on the Development and the Learning and Memory Abilities of Rat Offspring.Neurotoxicity research · 2020Article
- Subacute administration of both methcathinone and manganese causes basal ganglia damage in mice resembling that in methcathinone abusers.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Article
- Psychoactive Bath Salts and Neurotoxicity Risk.Turkish journal of pharmaceutical sciences · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The present review briefly explores the neurotoxic properties of methcathinone, mephedrone, methylone, and methylenedioxypyrovalerone (MDPV), four synthetic cathinones most commonly found in "bath salts." Cathinones are β-keto analogs of the commonly abused amphetamines and display pharmacological effects resembling cocaine and amphetamines, but despite their commonalities in chemical structures, synthetic cathinones possess distinct neuropharmacological profiles and produce unique effects. Among the similarities of synthetic cathinones with their non-keto analogs are their targeting of monoamine systems, the release of neurotransmitters, and their stimulant properties. Most of the literature on synthetic cathinones has focused on describing their properties as psychostimulants, their behavioral effects on locomotion, memory, and potential for abuse, whereas descriptions of their neurotoxic properties are not abundant. The biochemical gauges of neurotoxicity induced by non-keto analogs are well studied in humans and experimental animals and include their ability to induce neuroinflammation, oxidative stress, excitotoxicity, temperature alterations as well as dysregulation of neurotransmitter systems and induce changes in monoamine transporters and receptors. These neurotoxicity gauges will serve as parameters to discuss the effects of the four previously mentioned synthetic cathinones alone or in combination with either another cathinone or with some of their non-keto analogs. Bath salts are not a defined combination of drugs and may consist of one synthetic cathinone compound or combinations of more cathinones. Furthermore, this review also presents some of the mechanisms that are thought to underlie this toxicity. A better understanding of the cellular and molecular mechanisms involved in the synthetic cathinones-induced neurotoxicity should contribute to generate modern therapeutic approaches to prevent or attenuate the adverse consequences of use of these drugs in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.