Evidence map›Paper›PMID 27752990›Full record

ArticleStem cell reviews and reports2017

Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking.

Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Joseph B Moore, J Zhao, Ahmed Abdel-Latif, Marcin Wysoczynski, Mariusz Z Ratajczak

Open access · hybridAbstract read
In one paragraph

Article in Stem cell reviews and reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

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  8. Biomechanical cues as master regulators of hematopoietic stem cell fate.Cellular and molecular life sciences : CMLS · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mateusz AdamiakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street Rm. 107, Louisville, KY, 40202, USA.
Ahmed Abdelbaset-IsmailStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street Rm. 107, Louisville, KY, 40202, USA.
Joseph B MooreInstitute of Molecular Cardiology, University of Louisville, Louisville, KY, USA.
J ZhaoInstitute of Molecular Cardiology, University of Louisville, Louisville, KY, USA.
Ahmed Abdel-LatifDivision of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, USA.
Marcin WysoczynskiInstitute of Molecular Cardiology, University of Louisville, Louisville, KY, USA.
Mariusz Z RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street Rm. 107, Louisville, KY, 40202, USA. mzrata01@louisville.edu.
University of Louisville · USMedical University of Warsaw · PLUniversity of Kentucky · US

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7M
Novel mechanisms involving complement cascade in stem cell traffickingR01DK074720 · NIDDK · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2007 to 2020
$4.1M
BIOACTIVE LIPIDS IN STEM CELL HOMING AND MOBILIZATIONR01HL112788 · NHLBI · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2013 to 2016
$1.5M
Role of Bioactive Lipids in Stem Cell Mobilization and Homing in Cardiac IschemiaR56HL124266 · NHLBI · UNIVERSITY OF KENTUCKY · PI ABDEL-LATIF, AHMED · 2014 to 2014
$375k
NHLBI NIH HHS R01 HL112788NHLBI NIH HHS R56 HL124266NIDDK NIH HHS R01 DK074720NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

Nitric oxide (NO) is a gaseous free radical molecule involved in several biological processes related to inflammation, tissue damage, and infections. Based on reports that NO inhibits migration of granulocytes and monocytes, we became interested in the role of inducible NO synthetase (iNOS) in pharmacological mobilization of hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM) into peripheral blood (PB). To address the role of NO in HSPC trafficking, we upregulated or downregulated iNOS expression in hematopoietic cell lines. Next, we performed mobilization studies in iNOS

Indexed as

Gene Expression Regulation, EnzymologicAnimalsBlotting, WesternBone Marrow CellsCell AdhesionCell Line, TumorCell MovementCells, CulturedChemotaxisFemaleHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHeme Oxygenase-1HumansK562 CellsMice, Inbred C57BLHeme Oxygenase-1Nitric OxideNitric Oxide Synthase Type IIComplement cascadeHO-1iNOSNOStem cell homingStem cell mobilization

Identifiers

PMID27752990
PMCPMC5346113
OpenAlexW2535213284

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.