Evidence map›Paper›PMID 27752925›Full record

ReviewJournal of the Association for Research in Otolaryngology : JARO2016

Application of Mouse Models to Research in Hearing and Balance.

Kevin K Ohlemiller, Sherri M Jones, Kenneth R Johnson

Abstract readReview
In one paragraph

Review in Journal of the Association for Research in Otolaryngology : JARO, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Pharmacologic Inhibition of JAK1/2 Potentiates Aminoglycoside-Induced Ototoxicity.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026
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  19. The transcription factorFrontiers in cellular neuroscience · 2024
    Article
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin K OhlemillerDepartment of Otolaryngology, Central Institute for the Deaf, Fay and Carl Simons Center for Hearing and Deafness, Washington University School of Medicine, 660 S. Euclid, Saint Louis, MO, 63110, USA. kohlemiller@wustl.edu.
Sherri M JonesDepartment of Special Education and Communication Disorders, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Kenneth R JohnsonThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.

Funding

CLONING TWO NEW DEAFNESS MUTATIONSR01DC004301 · NIDCD · JACKSON LABORATORY · PI JOHNSON, KENNETH R · 2000 to 2017
$8.6M
NIDCD NIH HHS R01 DC004301
6 · The paper itself

Abstract

Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models.

Indexed as

HearingMiceModels, AnimalPostural BalanceAgingAnimalsGene ExpressionHearing LossVestibular Diseasesage-related hearing lossampullaeauditory neuronscochleadeafnessgenetic hearing losshair cellsinbredknockoutlateral wallmaculaemicenoise-induced hearing lossoutbredpresbycusisrecombinant inbredsacculesemicircular canalstria vascularisutriclevestibularvestibular testing

Identifiers

PMID27752925
PMCPMC5112220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.