Evidence map›Paper›PMID 27752803›Full record

ArticleNeurochemical research2016

Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats.

Tafheem Malik, Sheema Hasan, Shahid Pervez, Tasneem Fatima, Darakhshan Jabeen Haleem

Abstract read
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In one paragraph

Article in Neurochemical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Tafheem MalikNeurochemistry and Biochemical Neuropharmacology Unit, Department of Biochemistry, The University of Karachi, Karachi, 75270, Pakistan. tafheemm85@gmail.com.ORCID http://orcid.org/0000-0002-0975-1906
Sheema HasanHistopathology Unit, Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan.
Shahid PervezHistopathology Unit, Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan.
Tasneem FatimaDepartment of Anatomy, United Medical and Dental College, Karachi, Pakistan.
Darakhshan Jabeen HaleemNeurochemistry and Biochemical Neuropharmacology Unit, Department of Biochemistry, The University of Karachi, Karachi, 75270, Pakistan.
Aga Khan University Hospital · PKKarachi Medical and Dental College · PKNational University of Health Sciences · USUniversity of Karachi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.

Indexed as

AnimalsAntipsychotic AgentsAstrocytesBasal Ganglia DiseasesCaudate NucleusDyskinesia, Drug-InducedGliosisHaloperidolMaleMotor ActivityNigella sativaNucleus AccumbensPlant OilsRats, WistarTardive DyskinesiaAntipsychotic AgentsHaloperidolPlant OilsAstrogliosisCaudateDyskinesiaGlial fibrillary acidic proteinHaloperidolNigella sativa oilNissl bodiesNucleus accumbensParkinsonismRatsStriatum

Identifiers

PMID27752803
OpenAlexW2535059347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.