ArticleBioprocess and biosystems engineering2017
Investigation of the interactions of critical scale-up parameters (pH, pO
Article in Bioprocess and biosystems engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Data-Driven Approach for Bioreactor Monitoring and Prediction in Monoclonal Antibody Production.ACS omega · 2026Article
- Integrating text mining and knowledge graph to enhance biopharmaceutical process optimization.PloS one · 2026Article
- Review
- Impact of specific productivity and operation mode upon the biophysical properties of HIV-1 Gag-based virus-like particles.Applied microbiology and biotechnology · 2025Article
- Temporal Galactose-Manganese Feeding in Fed-Batch and Perfusion Bioreactors Modulates UDP-Galactose Pools for Enhanced mAb Glycosylation Homogeneity.Biotechnology and bioengineering · 2025Article
- Wheels turning: CHO cell modeling moves into a digital biomanufacturing era: Subtitle: CHO Metabolic Modeling.Computational and structural biotechnology journal · 2025Review
- Simplifying the detection and monitoring of protein glycosylation during in vitro glycoengineering.Scientific reports · 2023Article
- A novel approach to noninvasive monitoring of dissolved carbon dioxide in small-scale cell culture processes.Frontiers in bioengineering and biotechnology · 2022Article
- Review
- Model-assisted DoE software: optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses.Bioprocess and biosystems engineering · 2021Article
- An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes.Applied microbiology and biotechnology · 2021Review
- Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture.Scientific reports · 2021Article
- Digital Seed Train Twins and Statistical Methods.Advances in biochemical engineering/biotechnology · 2021Article
- Rapid development of clone-specific, high-performing perfusion media from established feed supplements.Biotechnology progress · 2020Article
- Towards robust cell culture processes - Unraveling the impact of media preparation by spectroscopic online monitoring.Engineering in life sciences · 2019Article
- Lectin bio-layer interferometry for assessing product quality of Fc- glycosylated immunoglobulin G.Biotechnology progress · 2019Article
- Article
- The Less the Better: How Suppressed Base Addition Boosts Production of Monoclonal Antibodies With Chinese Hamster Ovary Cells.Frontiers in bioengineering and biotechnology · 2019Article
- Elevated pCOEngineering in life sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding process parameter interactions and their effects on mammalian cell cultivations is an essential requirement for robust process scale-up. Furthermore, knowledge of the relationship between the process parameters and the product critical quality attributes (CQAs) is necessary to satisfy quality by design guidelines. So far, mainly the effect of single parameters on CQAs was investigated. Here, we present a comprehensive study to investigate the interactions of scale-up relevant parameters as pH, pO
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