ArticleEuropean journal of clinical pharmacology2017
Characteristics and drug use patterns of older antidepressant initiators in Germany.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Trends, Patterns and Associated User Characteristics of Antidepressant Prescriptions in Older Adults: A Nationwide Descriptive Cohort Study in Denmark.Drugs & aging · 2023Article
- Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.PloS one · 2021Article
- Drug interactions with oral anticoagulants in German nursing home residents: comparison between vitamin K antagonists and non-vitamin K antagonist oral anticoagulants based on two nested case-control studies.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Individual Antidepressants and the Risk of Fractures in Older Adults: A New User Active Comparator Study.Clinical epidemiology · 2020Article
- Antidepressants and the Risk of Hemorrhagic Stroke in the Elderly: a Nested Case-Control Study.Drug safety · 2019Article
- Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources.Pharmacoepidemiology and drug safety · 2019Article
- Article
- Duration of new antidepressant use and factors associated with discontinuation among community-dwelling persons with Alzheimer's disease.European journal of clinical pharmacology · 2019Article
- Claims Data Analysis on the Dispensing of Tricyclic Antidepressants Among Patients With Dementia in Germany.Frontiers in pharmacology · 2019Article
- Antidepressants and the risk of death in older patients with depression: A population-based cohort study.PloS one · 2019Article
- Antidepressants and the risk of traumatic brain injury in the elderly: differences between individual agents.Clinical epidemiology · 2019Article
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Authors and funding
6 authors.
Funding
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Abstract
purposeThe purpose of this study was to investigate characteristics, drug use patterns, and predictors for treatment choice in older German patients initiating antidepressant (AD) treatment.
methodsUsing the German Pharmacoepidemiological Research Database, we identified a cohort of AD initiators aged at least 65 years between 2005 and 2011. Potential indications, co-morbidity, and co-medication as well as treatment patterns such as the duration of the first treatment episode were assessed. In addition, a logistic regression model was used to identify independent predictors for initiating treatment with tricyclic ADs (TCAs) compared to selective serotonin reuptake inhibitors (SSRIs).
resultsOverall, 508,810 individuals were included in the cohort. About 55 % of patients initiated AD treatment with TCAs, followed by 22 % receiving SSRIs. During the study period, a decrease of treatment initiation with TCAs was observed. Higher age and male sex as well as being diagnosed with depression were highly associated with SSRI treatment, whereas pain and sleeping disorders were strong predictors for initiating TCA treatment. The duration of the first treatment episode was substantially longer in SSRI users compared to TCA initiators (median 119 vs. 43 days).
conclusionsPotential indications and drug use patterns in older German AD initiators varied substantially for different drug classes and single agents. Given the anticholinergic and sedative properties of TCAs, the frequent use of this drug class though probably related to indications such as pain was remarkable.
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