Evidence map›Paper›PMID 27752690›Full record

ArticleOrganic & biomolecular chemistry2016

Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes.

Zhigang Wu, Yunpeng Liu, Cheng Ma, Lei Li, Jing Bai, Lauren Byrd-Leotis, Yi Lasanajak, Yuxi Guo, Liuqing Wen, He Zhu and 8 more

Open access · greenAbstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 48 citations in OpenAlex.

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  7. Recent Advances in the Chemical Biology ofMolecules (Basel, Switzerland) · 2021
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  11. Article
  12. Oligosaccharide Synthesis and Translational Innovation.Journal of the American Chemical Society · 2019
    Review
  13. Synthesis ofFrontiers in immunology · 2019
    Review
  14. Review
  15. Facile Chemoenzymatic Synthesis of O-Mannosyl Glycans.Angewandte Chemie (International ed. in English) · 2018
    Article
  16. Article
  17. Article
  18. An enzymatic strategy to asymmetrically branched N-glycans.Organic & biomolecular chemistry · 2017
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Zhigang WuDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
Yunpeng LiuDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
Cheng MaDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
Lei LiDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
Jing BaiCollege of Life Science, Hebei Normal University, Shijiazhuang, Hebei 050024, China. guanwanyi@mail.hebtu.edu.cn.
Lauren Byrd-LeotisDepartments of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Yi LasanajakDepartment of Biochemistry and Emory Comprehensive Glycomics Core, Emory University School of Medicine, Atlanta, GA 30322, USA.
Yuxi GuoDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
Liuqing WenDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
He ZhuDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
Jing SongDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
Yanhong LiDepartment of Chemistry, University of California, Davis, CA 95616, USA. xiichen@ucdavis.edu.
David A SteinhauerDepartments of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
David F SmithDepartment of Biochemistry and Emory Comprehensive Glycomics Core, Emory University School of Medicine, Atlanta, GA 30322, USA.
Baohua ZhaoCollege of Life Science, Hebei Normal University, Shijiazhuang, Hebei 050024, China. guanwanyi@mail.hebtu.edu.cn.
Xi ChenDepartment of Chemistry, University of California, Davis, CA 95616, USA. xiichen@ucdavis.edu.
Wanyi GuanDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu and College of Life Science, Hebei Normal University, Shijiazhuang, Hebei 050024, China. guanwanyi@mail.hebtu.edu.cn.
Peng George WangDepartment of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA. pwang11@gsu.edu.
Georgia State University · USAID Atlanta · USEmory University · USMosaiques Diagnostics and Therapeutics (Germany) · DEComprehensive Clinical Research · USHebei Normal University · CNShijiazhuang University · CNUniversity of California, Davis · USUniversity of California System · US

Funding

Facile Synthesis of O-Glycans and O-GlycopeptidesU01GM116263 · NIGMS · GEORGIA STATE UNIVERSITY · PI LI, LEI · 2015 to 2018
$2.2M
Oligosaccharides as antimicrobials and prebioticsR01HD065122 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI · 2010 to 2013
$1.8M
The role of NA in virus receptor interaction and HA:NA functional balanceF31AI115968 · NIAID · EMORY UNIVERSITY · PI BYRD-LEOTIS, LAUREN · 2015 to 2016
$79k
NIAID NIH HHS F31 AI115968NICHD NIH HHS R01 HD065122NIGMS NIH HHS U01 GM116263
6 · The paper itself

Abstract

Glycans play diverse roles in a wide range of biological processes. Research on glycan-binding events is essential for learning their biological and pathological functions. However, the functions of terminal and internal glycan epitopes exhibited during binding with glycan-binding proteins (GBPs) and/or viruses need to be further identified. Therefore, a focused library of 36 biantennary asparagine (Asn)-linked glycans with some presenting tandem glycan epitopes was synthesized via a combined Core Isolation/Enzymatic Extension (CIEE) and one-pot multienzyme (OPME) synthetic strategy. These N-glycans include those containing a terminal sialyl N-acetyllactosamine (LacNAc), sialyl Lewis x (sLe

Indexed as

Chemistry Techniques, SyntheticEnzymesEpitopesPolysaccharidesEnzymesEpitopesPolysaccharides

Identifiers

PMID27752690
PMCPMC5951163
OpenAlexW2529964591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.