ArticleClinical and experimental emergency medicine2015
The effect of liver disease on lactate normalization in severe sepsis and septic shock: a cohort study.
Article in Clinical and experimental emergency medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 85 citations in OpenAlex.
- Combined metabolic risk and admission lactate-to-bicarbonate ratio in critically ill children: a retrospective pediatric ıntensive care cohort study.European journal of pediatrics · 2026Article
- Association between lactate-to-albumin ratio and mortality in patients with sepsis-induced coagulopathy: a retrospective cohort study.Scientific reports · 2026Article
- Article
- Association of lactate-to-albumin ratio with 28-day mortality in elderly sepsis patients: a retrospective MIMIC-IV database analysis.BMC infectious diseases · 2026Article
- Prognostic utility of the lactate-to-albumin ratio for predicting 28-day all-cause mortality in critically ill cases with acute sepsis: A retrospective study on the basis of MIMIC-IV critical care database.Journal of medical biochemistry · 2026Article
- Machine Learning-Guided Multi-Omics Integration Identifies UGCG as a Candidate Lipid Metabolic Biomarker and Potential Therapeutic Target in Sepsis.Journal of inflammation research · 2026Article
- Persistent lactic acidosis in ALK-positive anaplastic large cell lymphoma: a case report and literature review.Frontiers in oncology · 2026Article
- Sepsis in end-stage liver disease and acute-on-chronic liver failure: pathophysiology, diagnostic challenges, and pharmacological management.Frontiers in pharmacology · 2026Review
- Observational
- The association between the lactate to albumin ratio and all-cause mortality in cardiac arrest patients: an analysis of the MIMIC-IV database.European journal of medical research · 2025Article
- Evaluation of Hypoxia Markers in Critically Ill Patients Categorized by Their Burden of Organ Dysfunction: A Novel Approach to Detect Pathophysiological and Clinical Relevance in a Secondary Analysis of a Prospective Observational Study.International journal of molecular sciences · 2025Observational
- Cardiometabolic shock: understanding the final turns of the downward spiral.Frontiers in cardiovascular medicine · 2025Review
- Prognostic value of the lactate-albumin ratio in trauma: A comparison with shock index and injury severity score.PloS one · 2025Observational
- The prognostic utility of Lactate/Albumin*Age score in septic patient with normal lactate level.Heliyon · 2024Article
- Article
- Mortality Prediction by Kinetic Parameters of Lactate and S-Adenosylhomocysteine in a Cohort of Critically Ill Patients.International journal of molecular sciences · 2024Article
- Serum lactate and mean arterial pressure thresholds in patients with cirrhosis and septic shock.Hepatology communications · 2024Observational
- Association between lactate/albumin ratio and all-cause mortality in critical patients with acute myocardial infarction.Scientific reports · 2023Article
- S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study.International journal of molecular sciences · 2023Article
- Association between lactate/albumin ratio and mortality in patients with heart failure after myocardial infarction.ESC heart failure · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the effect of liver disease (LD) on lactate clearance during early sepsis resuscitation.
methodsThis is a multicenter randomized clinical trial. An initial lactate >2 mmol/L and subsequent serum lactate measurement within 6 hours were required for inclusion. LD was categorized by two methods: 1) past medical history (PMH) categorized as no LD, mild LD (no Child's score criteria, but PMH of hepatitis B/C), cirrhosis; and 2) measurable liver dysfunction determined by the liver component of the sequential organ failure assessment (L-SOFA) score as no dysfunction (L-SOFA score 0), mild dysfunction (score 1), moderate-severe dysfunction (score 2 to 4). Primary outcome was the rate of lactate normalization.
resultsOne hundred eighty-seven patients were included. When categorized by PMH, 169 patients had no LD, 6 mild LD, and 12 cirrhosis. 63/169 (37%) of patients with no LD achieved lactate normalization, compared to 4/6 (67%) with mild LD, and 1/12 (8%) with cirrhosis (P<0.03). Categorized by L-SOFA score, 59/124 (47%) patients with L-SOFA 0 achieved lactate normalization, compared to 6/31 (19%) with L-SOFA 1, and 3/32 (9%) with L-SOFA 2-4 (P<0.01). Relative lactate clearance [(initial lactate-subsequent lactate)/initial lactate] was lower in patients with more advanced LD by PMH (37.7 vs. 40.4 vs. 21.8, P=0.07), and lower with increasing L-SOFA score (42.0 vs. 30.1 vs. 23.4, P=0.01).
conclusionLiver dysfunction was significantly associated with impaired lactate clearance and normalization during the early resuscitation of sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.