ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2016
Modeling practice effects in healthy middle-aged participants of the Alzheimer and Families parent cohort.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive Functioning of Unaffected First-degree Relatives of Individuals With Late-onset Alzheimer's Disease: A Systematic Literature Review and Meta-analysis.Neuropsychology review · 2023Pooled it
- Validation of International Cognitive Ability Resource (ICAR) Implemented in Mobile Toolbox (MTB).Journal of Intelligence · 2025Article
- Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Amyloid and tau may moderate practice effects in semantic and episodic memory in a cognitively unimpaired at-risk sample.Brain communications · 2025Article
- Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Practice Effect of Repeated Cognitive Tests Among Older Adults: Associations With Brain Amyloid Pathology and Other Influencing Factors.Frontiers in aging neuroscience · 2022Article
- Dynamic modeling of practice effects across the healthy aging-Alzheimer's disease continuum.Frontiers in aging neuroscience · 2022Article
- Trends in the Risk of Cognitive Impairment in the United States, 1996-2014.Epidemiology (Cambridge, Mass.) · 2020Article
- Lower practice effects as a marker of cognitive performance and dementia risk: A literature review.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- The classification of mild cognitive impairment or healthy ageing improves when including practice effects derived from a semantic verbal fluency task.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRepetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently developing Alzheimer's disease (AD).
methodsTo explore the relationship between sociodemographic factors, AD family history (FH), and
resultsPEs were observed in all measures. Sociodemographic variables did not show a uniform effect on PE. Baseline score was the strongest predictor of change, being inversely related to PE magnitude. Significant effects of the interaction term DISCUSSION: PEs exert a relevant effect in cognitive outcomes at retest and, accordingly, they must be taken into consideration in clinical trials. The magnitude of PE in processing speed and working memory could be of special interest for the development of cognitive markers of preclinical AD.
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