Evidence map›Paper›PMID 27752517›Full record

ArticleAnnals of clinical and translational neurology2016

Respiratory training in an individual with amyotrophic lateral sclerosis.

Lauren C Tabor, Karen M Rosado, Raele Robison, Karen Hegland, Ianessa A Humbert, Emily K Plowman

4 registry-linked trialsAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03604822 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Measuring the Effects of a Music Therapy Protocol on Respiratory and Bulbar Functions of Patients With Early and Mid-stage Amyotrophic Lateral Sclerosis: Mixed Methods Single Case Study Series

TypeinterventionalSponsorAlisa AprelevaRan2017 to 2020Enrolled8ConditionsMotor Neuron Disease, Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis), Dysarthria, Flaccid, Dysarthria, SpasticArmsMusic therapy
NCT04009408 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Interventional Study of Expiratory Muscle Strength Training as a Treatment in Neuromuscular Disorders

TypeinterventionalSponsorUniversity of CalgaryRan2022 to 2022Enrolled20ConditionsOculopharyngeal Muscular Dystrophy, Muscular Dystrophies, Myopathy, HereditaryArmsExpiratory muscle strength therapy (EMST150, Aspire LLC)
NCT04468191 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Quantifying Fatigue of the Respiratory and Swallowing Musculature in Patients With Amyotrophic Lateral Sclerosis

TypeinterventionalSponsorCara DonohueRan2021 to 2021Enrolled0ConditionsAmyotrophic Lateral Sclerosis, Dysphagia, Dyspnea, Respiration DisordersArmsExperimental expiratory muscle strength training (EMST), Sham expiratory muscle strength training (EMST)
NCT07606235 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS

TypeinterventionalSponsorNova Southeastern UniversityRan2026 to 2026Enrolled5ConditionsAmyotrophic Lateral Sclerosis (ALS), Dysphagia, DystussiaArmsTranscutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lauren C TaborDepartment of Physical Therapy University of Florida Gainesville Florida; Swallowing Systems Core University of Florida Gainesville Florida.
Karen M RosadoSwallowing Systems Core University of Florida Gainesville Florida.
Raele RobisonDepartment of Physical Therapy University of Florida Gainesville Florida; Swallowing Systems Core University of Florida Gainesville Florida.
Karen HeglandSpeech, Language and Hearing Science Department University of Florida Gainesville Florida.
Ianessa A HumbertSwallowing Systems Core University of Florida Gainesville Florida; Speech, Language and Hearing Science Department University of Florida Gainesville Florida.
Emily K PlowmanDepartment of Physical Therapy University of Florida Gainesville Florida; Swallowing Systems Core University of Florida Gainesville Florida; Speech, Language and Hearing Science Department University of Florida Gainesville Florida.

Funding

Training In Rehabilitation and Neuromuscular PlasticityT32HD043730 · NICHD · UNIVERSITY OF FLORIDA · PI DAVID D FULLER · 2003 to 2026
$5.3M
Effects of Strength Training on Bulbar Function in Amyotrophic Lateral SclerosisR21HD075327 · NICHD · UNIVERSITY OF SOUTH FLORIDA · PI RICHTER, JOEL E · 2013 to 2014
$396k
NICHD NIH HHS R21 HD075327NICHD NIH HHS T32 HD043730
6 · The paper itself

Abstract

We examined the impact of expiratory muscle strength training on maximum expiratory pressure, cough spirometry, and disease progression in a 71-year-old male with amyotrophic lateral sclerosis. Maximum expiratory pressure declined 9% over an 8-week sham training period, but subsequently improved by 102% following 8 weeks of expiratory muscle strength training. Improvements in cough spirometry and mitigated disease progression were also observed post expiratory muscle strength training. Improvements in maximum expiratory pressures were maintained 6 months following expiratory muscle strength training and were 79% higher than baseline data obtained 301 days prior. In this spinal-onset amyotrophic lateral sclerosis patient, respiratory training improved subglottic air pressure generation and sequential cough generation.

Identifiers

PMID27752517
PMCPMC5048392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.