ArticleEnvironmental sciences Europe2016
Criteria for Reporting and Evaluating ecotoxicity Data (CRED): comparison and perception of the Klimisch and CRED methods for evaluating reliability and relevance of ecotoxicity studies.
Article in Environmental sciences Europe, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Organic Pollutants Associated with Plastic Debris in Marine Environment: A Systematic Review of Analytical Methods, Occurrence, and Characteristics.International journal of environmental research and public health · 2023Pooled it
- Guidance on the use of read-across for chemical safety assessment in food and feed.EFSA journal. European Food Safety Authority · 2025Article
- From papers to RDF-based integration of physicochemical data and adverse outcome pathways for nanomaterials.Journal of cheminformatics · 2024Article
- The NOAA NCEI marine microplastics database.Scientific data · 2023Article
- A Critical Review of the Availability, Reliability, and Ecological Relevance of Arctic Species Toxicity Tests for Use in Environmental Risk Assessment.Environmental toxicology and chemistry · 2022Review
- Coral Ecotoxicological Data Evaluation for the Environmental Safety Assessment of Ultraviolet Filters.Environmental toxicology and chemistry · 2021Article
- Evaluating reliability and risk of bias of in vivo animal data for risk assessment of chemicals - Exploring the use of the SciRAP tool in a systematic review context.Environment international · 2021Article
- Microplastics in freshwaters and drinking water: Critical review and assessment of data quality.Water research · 2019Review
- Reliability and relevance evaluations of REACH data.Toxicology research · 2019Article
- Quality Criteria for the Analysis of Microplastic in Biota Samples: A Critical Review.Environmental science & technology · 2018Article
- A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making.Journal of applied toxicology : JAT · 2018Article
- The Swiss Ecotox Centre: bridging the gap between research and application.Environmental sciences Europe · 2018Review
- Making the most of expert judgment in hazard and risk assessment of chemicals.Toxicology research · 2017Review
- Erratum to: Criteria for Reporting and Evaluating ecotoxicity Data (CRED): comparison and perception of the Klimisch and CRED methods for evaluating reliability and relevance of ecotoxicity studies.Environmental sciences Europe · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe regulatory evaluation of ecotoxicity studies for environmental risk and/or hazard assessment of chemicals is often performed using the method established by Klimisch and colleagues in 1997. The method was, at that time, an important step toward improved evaluation of study reliability, but lately it has been criticized for lack of detail and guidance, and for not ensuring sufficient consistency among risk assessors.
resultsA new evaluation method was thus developed: Criteria for Reporting and Evaluating ecotoxicity Data (CRED). The CRED evaluation method aims at strengthening consistency and transparency of hazard and risk assessment of chemicals by providing criteria and guidance for reliability and relevance evaluation of aquatic ecotoxicity studies. A two-phased ring test was conducted to compare and characterize the differences between the CRED and Klimisch evaluation methods. A total of 75 risk assessors from 12 countries participated. Results show that the CRED evaluation method provides a more detailed and transparent evaluation of reliability and relevance than the Klimisch method. Ring test participants perceived it to be less dependent on expert judgement, more accurate and consistent, and practical regarding the use of criteria and time needed for performing an evaluation.
conclusionsWe conclude that the CRED evaluation method is a suitable replacement for the Klimisch method, and that its use may contribute to an improved harmonization of hazard and risk assessments of chemicals across different regulatory frameworks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.