Evidence map›Paper›PMID 27752257›Full record

ArticleFrontiers in immunology2016

(1→3)-β-d-Glucan: A Biomarker for Microbial Translocation in Individuals with Acute or Early HIV Infection?

Martin Hoenigl, Josué Pérez-Santiago, Masato Nakazawa, Michelli Faria de Oliveira, Yonglong Zhang, Malcolm A Finkelman, Scott Letendre, Davey Smith, Sara Gianella

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Invasive Candidiasis in the Intensive Care Unit: Where Are We Now?Journal of fungi (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Invasive Aspergillosis in the Intensive Care Unit.Journal of fungi (Basel, Switzerland) · 2025
    Review
  8. One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia.American journal of respiratory and critical care medicine · 2024
    Article
  9. Fungal translocation measured by serum 1,3-ß-D-glucan correlates with severity and outcome of liver cirrhosis-A pilot study.Liver international : official journal of the International Association for the Study of the Liver · 2023
    Article
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Martin HoeniglDepartment of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA; Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Department of Internal Medicine, Division of Pulmonology, Medical University of Graz, Graz, Austria.
Josué Pérez-SantiagoDepartment of Medicine, Division of Infectious Diseases, University of California San Diego , San Diego, CA , USA.
Masato NakazawaDepartment of Medicine, AntiViral Research Center, University of California San Diego , San Diego, CA , USA.
Michelli Faria de OliveiraDepartment of Medicine, Division of Infectious Diseases, University of California San Diego , San Diego, CA , USA.
Yonglong ZhangClinical Development, Associates of Cape Cod, Inc. , Falmouth, MA , USA.
Malcolm A FinkelmanClinical Development, Associates of Cape Cod, Inc. , Falmouth, MA , USA.
Scott LetendreDepartment of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA; Department of Neurosciences, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA, USA.
Davey SmithDepartment of Medicine, Division of Infectious Diseases, University of California San Diego , San Diego, CA , USA.
Sara GianellaDepartment of Medicine, Division of Infectious Diseases, University of California San Diego , San Diego, CA , USA.
University of California, San Diego · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Translational Methamphetamine AIDS Research Center (TMARC)P50DA026306 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2009 to 2018
$33.9M
Transmission ProbabilityP01AI074621 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2008 to 2012
$23.1M
Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
Southern California Primary Infection ProgramU01AI043638 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICHMAN, DOUGLAS D · 1998 to 2010
$21.3M
Prospective Memory in HIV-1 InfectionR01MH073419 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WOODS, STEVEN PAUL · 2005 to 2017
$6.6M
Interdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2M
Molecular Epidemiology for HIV Prevention for Drug Users and Other Risk Groups DP1DA034978 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2016
$4.1M
Developing Research At The Interface Of HIV And AgingR24AG044325 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HIGH, KEVIN P. · 2013 to 2017
$2.4M
Effects of Host and Viral Aging on NeurocognitionR01MH097520 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2016
$2.0M
NIAID NIH HHS K24 AI100665NIAID NIH HHS P01 AI074621NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI036214NIAID NIH HHS R24 AI106039NIAID NIH HHS U01 AI043638NIA NIH HHS R24 AG044325NIDA NIH HHS DP1 DA034978NIDA NIH HHS P50 DA026306NIMH NIH HHS K24 MH097673NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH073419NIMH NIH HHS R01 MH097520NIMH NIH HHS R01 MH101012NIMH NIH HHS R25 MH081482
6 · The paper itself

Abstract

backgroundThe extent of gut microbial translocation, which plays roles in HIV disease progression and non-AIDS comorbidities, appears to vary with the composition of the gut microbiome, particularly the presence of

methodsStudy samples were collected longitudinally during study visits at weeks 0, 12, and 24 in a cohort of 11 HIV-infected men starting antiretroviral therapy during AEH. Blood plasma levels of BDG, soluble cluster of differentiation 14 (sCD14) and lipopolysaccharide (LPS) were measured and then correlated with the proportion of

resultsMean BDG and sCD14 levels across subjects were associated with

conclusionBDG and sCD14 may be indicators of low

Indexed as

acute HIV infectionbeta-d-glucanHIVLactobacillalesmicrobial translocationmicrobiome

Identifiers

PMID27752257
PMCPMC5046804
OpenAlexW2529144196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.