ArticleScientific reports2016
Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
155 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A 'Ménage à Trois'?Alcohol and alcoholism (Oxford, Oxfordshire) · 2017Pooled it
- Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- A Microbial Signature of Psychological Distress in Irritable Bowel Syndrome.Psychosomatic medicine · 2018Trial
- Trial
- GutGut microbes · 2026Article
- The Adolescent Microbiome-Gut-Brain Axis: Development, Mechanisms, and Translational Perspectives.Nutrients · 2026Review
- The role of the gut microbiome in nicotine withdrawal and dependence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving.Brain, behavior, & immunity - health · 2026Article
- Behavioral flexibility and gut microbiome as potential predictors of oral oxycodone self-administration.bioRxiv : the preprint server for biology · 2026Article
- If you give a mouse a poopsicle: a novel fecal microbiota transplant method for exploring the role of the gut microbiome in stress-related outcomes in mice.bioRxiv : the preprint server for biology · 2026Article
- Brief antibiotics exposure during adolescence produces persistent effects on the microbiome and fentanyl-seeking during adulthood in rats.Frontiers in behavioral neuroscience · 2026Article
- Serum Zonulin Levels in Patients with Heroin Addiction.Sisli Etfal Hastanesi tip bulteni · 2026Article
- If you give a mouse a poopsicle: a novel fecal microbiota transplant method for exploring the role of the gut microbiome in stress-related outcomes in mice.Frontiers in immunology · 2026Article
- From bugs to behavior: targeting the gut-brain interface for addiction therapeutics.Gut microbes · 2025Review
- Translational Evidence of Immunomodulation by Addictive Drugs: Mechanisms and Therapeutic Targets.Journal of neuroimmunology · 2025Article
- Worldwide Research Trends on Substance Use Disorder-Related Inflammatory Imbalances: A Bibliometric Analysis.CNS neuroscience & therapeutics · 2025Article
- Brief exposure to oral antibiotics has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice.Brain, behavior, and immunity · 2025Article
- Article
- Microbiome-derived metabolites in substance use disorders: Mechanisms and implications.Annals of the New York Academy of Sciences · 2025Review
- Gut microbiome depletion modulates cocaine-induced behavioral and transcriptional responses in female mice.Journal of neuroimmunology · 2025Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Addiction to cocaine and other psychostimulants represents a major public health crisis. The development and persistence of addictive behaviors comes from a complex interaction of genes and environment - the precise mechanisms of which remain elusive. In recent years a surge of evidence has suggested that the gut microbiome can have tremendous impact on behavioral via the microbiota-gut-brain axis. In this study we characterized the influence of the gut microbiota on cocaine-mediated behaviors. Groups of mice were treated with a prolonged course of non-absorbable antibiotics via the drinking water, which resulted in a substantial reduction of gut bacteria. Animals with reduced gut bacteria showed an enhanced sensitivity to cocaine reward and enhanced sensitivity to the locomotor-sensitizing effects of repeated cocaine administration. These behavioral changes were correlated with adaptations in multiple transcripts encoding important synaptic proteins in the brain's reward circuitry. This study represents the first evidence that alterations in the gut microbiota affect behavioral response to drugs of abuse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.