Evidence map›Paper›PMID 27752092›Full record

ArticleScientific reports2016

Massive release of extracellular vesicles from cancer cells after photodynamic treatment or chemotherapy.

Kelly Aubertin, Amanda K A Silva, Nathalie Luciani, Ana Espinosa, Aurélie Djemat, Dominique Charue, François Gallet, Olivier Blanc-Brude, Claire Wilhelm

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 143 citations in OpenAlex.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Kelly AubertinLaboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
Amanda K A SilvaLaboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
Nathalie LucianiLaboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
Ana EspinosaLaboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
Aurélie DjematAnimalerie BUFFON. Institut Jacques Monod. UMR 7592 CNRS - Université Paris Diderot, 75205 PARIS Cedex 13, France.
Dominique CharueParCC Paris Cardiovascular Center, INSERM UMRs 970, Université Paris Descartes, PRES Sorbonne-Paris-Cité, et Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 56 rue Leblanc, 75908 Paris CEDEX 15, France.
François GalletLaboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
Olivier Blanc-BrudeParCC Paris Cardiovascular Center, INSERM UMRs 970, Université Paris Descartes, PRES Sorbonne-Paris-Cité, et Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 56 rue Leblanc, 75908 Paris CEDEX 15, France.
Claire WilhelmLaboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
Université Paris Cité · FRCentre National de la Recherche Scientifique · FRParis Cardiovascular Research Center · FRInstitut Jacques Monod · FRLaboratoire Matière et Systèmes Complexes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy is an emerging cancer treatment that is particularly adapted for localized malignant tumor. The phototherapeutic agent is generally injected in the bloodstream and circulates in the whole organism as a chemotherapeutic agent, but needs light triggering to induce localized therapeutic effects. We found that one of the responses of in vitro and in vivo cancer cells to photodynamic therapy was a massive production and emission of extracellular vesicles (EVs): only 1 hour after the photo-activation, thousands of vesicles per cell were emitted in the extracellular medium. A similar effect has been found after treatment with Doxorubicin (chemotherapy), but far less EVs were produced, even 24 hours after the treatment. Furthermore, we found that the released EVs could transfer extracellular membrane components, drugs and even large intracellular objects to naive target cells. In vivo, photodynamic treatment and chemotherapy increased the levels of circulating EVs several fold, confirming the vast induction of cancer cell vesiculation triggered by anti-cancer therapies.

Indexed as

AnimalsCell Line, TumorDoxorubicinExtracellular VesiclesGene Expression Regulation, NeoplasticHumansMacrophagesMaleMiceMicroRNAsPhotochemotherapyProstatic NeoplasmsXenograft Model Antitumor AssaysDoxorubicinMicroRNAs

Identifiers

PMID27752092
PMCPMC5067517
OpenAlexW2533480443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.