ArticleMolecular psychiatry2018
Inhibition of STEP
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Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Unraveling the enigma: Post-translational modifications in psychiatric disorders and their regulatory mechanisms.Journal of translational internal medicine · 2026Article
- Phosphatase Signaling as a Therapeutic Strategy in Schizophrenia.International journal of molecular sciences · 2026Review
- Lack of striatal-enriched protein tyrosine phosphatase affected the serotonin system, behavior, and brain morphology in mice.Frontiers in psychiatry · 2025Article
- Probing the molecular and cellular pathological mechanisms of schizophrenia using human induced pluripotent stem cell models.Schizophrenia research · 2024Review
- Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells.Acta neuropathologica communications · 2022Review
- Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells.Translational psychiatry · 2022Review
- Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation.Stem cell reports · 2022Review
- Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty?Frontiers in cell and developmental biology · 2022Review
- STEP inhibition prevents Aβ-mediated damage in dendritic complexity and spine density in Alzheimer's disease.Experimental brain research · 2021Article
- The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer's Disease and Other Neurological Disorders.Frontiers in cell and developmental biology · 2021Review
- Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids.Molecular psychiatry · 2020Article
- Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells.Advances in neurobiology · 2020Review
- Disruption of Striatal-Enriched Protein Tyrosine Phosphatase Signaling Might Contribute to Memory Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.Neurochemical research · 2019Article
- Drug discovery in psychopharmacology: from 2D models to cerebral organoids .Dialogues in clinical neuroscience · 2019Review
- New considerations for hiPSC-based models of neuropsychiatric disorders.Molecular psychiatry · 2019Review
- Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.International journal of molecular sciences · 2018Review
- Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEPMolecular neurobiology · 2018Article
- Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders.Molecular psychiatry · 2018Article
- Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats.Addiction biology · 2018Article
Corrections and comments
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Authors and funding
23 authors at 8 institutions in 1 country.
J XuChild Study Center, Yale University, New Haven, CT, USA.
B J HartleyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
P KurupChild Study Center, Yale University, New Haven, CT, USA.
A PhillipsHussman Institute for Autism, Baltimore, MD, USA.
A TopolDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M XuDepartment of Psychiatry, Yale University, New Haven, CT, USA.
C OnonenyiChild Study Center, Yale University, New Haven, CT, USA.
E FoscueChild Study Center, Yale University, New Haven, CT, USA.
S-M HoFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
T D BaguleyDepartment of Chemistry, Yale University, New Haven, CT, USA.
N CartyChild Study Center, Yale University, New Haven, CT, USA.
C S BarrosDorris Neuroscience Center, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA.
U MüllerDorris Neuroscience Center, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA.
S GuptaUC Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
P GochmanChildhood Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
J RapoportChildhood Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
J A EllmanDepartment of Chemistry, Yale University, New Haven, CT, USA.
C PittengerDepartment of Psychiatry, Yale University, New Haven, CT, USA.
B AronowUC Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
A C NairnDepartment of Psychiatry, Yale University, New Haven, CT, USA.
M W NestorHussman Institute for Autism, Baltimore, MD, USA.
P J LombrosoChild Study Center, Yale University, New Haven, CT, USA.
K J BrennandDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yale University · USAllen Institute for Brain Science · USCincinnati Children's Hospital Medical Center · USHussman Institute for Autism · USScripps Research Institute · USIcahn School of Medicine at Mount Sinai · USNational Institute of Mental Health · USNational Institutes of Health · US
Funding
Childhood Onset SchizophreniaZIAMH002581 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RAPOPORT, JUDITH L. · 2009 to 2017
$25.5MMultimodal analysis of high-risk psychosis mutations in induced neuronal cellsU19MH104172 · NIMH · STANFORD UNIVERSITY · PI LEVINSON, DOUGLAS FREDERICK, SUDHOF, THOMAS C. · 2014 to 2018
$9.7MC57BI/6 Mouse Lines Expressing CRE-Recombinase in the Nervous SystemU01MH078833 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI MUELLER, ULRICH · 2006 to 2010
$7.7MHigher Order Chromatin and Genetic Risk for SchizophreniaR01MH106056 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, BRENNAND, KRISTEN JENNIFER · 2015 to 2023
$6.7MSubstrate Activity Screening: A New Approach to Inhibitor DiscoveryR01GM054051 · NIGMS · YALE UNIVERSITY · PI ELLMAN, JONATHAN A · 1997 to 2016
$5.2MMOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTPSR01MH052711 · NIMH · YALE UNIVERSITY · PI LOMBROSO, PAUL J · 1999 to 2014
$5.0MContrasting causal microRNAs in forebrain and midbrain COS hiPSC neural cellsR01MH101454 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BRENNAND, KRISTEN JENNIFER · 2013 to 2017
$2.8MPathophysiologically Realistic Mouse Models of Neuropsychiatric Disease: TouretteR01MH091861 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2010 to 2014
$2.0MThe Role of STEP in SchizophreniaR01MH091037 · NIMH · YALE UNIVERSITY · PI LOMBROSO, PAUL J · 2011 to 2015
$1.8MModeling the contribution of common variants to schizophrenia riskR56MH101454 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BRENNAND, KRISTEN JENNIFER, HUCKINS, LAURA MARIANNE · 2018 to 2019
$1.5MNIGMS NIH HHS R01 GM054051NIMH NIH HHS R01 MH052711NIMH NIH HHS R01 MH091037NIMH NIH HHS R01 MH091861NIMH NIH HHS R01 MH101454NIMH NIH HHS R01 MH106056NIMH NIH HHS R56 MH101454NIMH NIH HHS U01 MH078833NIMH NIH HHS U19 MH104172
Abstract
The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR) internalization through dephosphorylation of GluN2B and inactivation of the kinases extracellular signal-regulated kinase 1/2 and Fyn. Here we show that STEP
Indexed as
AnimalsDisease Models, AnimalFemaleHumansInduced Pluripotent Stem CellsMaleMiceMice, Inbred C57BLMice, KnockoutNeuregulin-1NeuronsPhosphorylationProtein Tyrosine PhosphatasesRatsReceptors, N-Methyl-D-AspartateSchizophreniaNeuregulin-1Nrg1 protein, mouseProtein Tyrosine PhosphatasesReceptors, N-Methyl-D-Aspartatestriatal-enriched tyrosine phosphatase 61, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.