Evidence map›Paper›PMID 27752075›Full record

Trial reportMolecular psychiatry2018

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial.

R E Frye, J Slattery, L Delhey, B Furgerson, T Strickland, M Tippett, A Sailey, R Wynne, S Rose, S Melnyk and 3 more

3 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 101 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 6 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02839915 phase2active not recruitingnot on this mapstarted 2020, after this paper: background citation

Leucovorin for the Treatment of Language Impairment in Children With Autism Spectrum Disorder

TypeinterventionalSponsorSouthwest Autism Research & Resource CenterRan2020 to 2026Enrolled56ConditionsAutism Spectrum DisorderArmsFolinic Acid, Placebo
NCT04060017 phase2active not recruitingnot on this mapstarted 2020, after this paper: background citation

Early Treatment of Language Impairment in Young Children With Autism Spectrum Disorder With Leucovorin Calcium

TypeinterventionalSponsorSouthwest Autism Research & Resource CenterRan2020 to 2026Enrolled80ConditionsAutism Spectrum Disorder, Language DisordersArmsLevoleucovorin Calcium, Placebo
NCT04060030 phase2recruitingnot on this mapstarted 2020, after this paper: background citation

Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism

TypeinterventionalSponsorSouthwest Autism Research & Resource CenterRan2020 to 2026Enrolled80ConditionsAutism Spectrum Disorder, Language DisordersArmsLevoleucovorin Calcium, Placebo
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 6 syntheses or guidelines pooled it, 198 citations in OpenAlex.

  1. Pooled it
  2. Complementary and Alternative Medicine for Autism - A Systematic Review.Journal of autism and developmental disorders · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Thyroid hormone and folinic acid in young children with Down syndrome: the phase 3 ACTHYF trial.Genetics in medicine : official journal of the American College of Medical Genetics · 2020
    Trial
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. A Developmental Neuroimmune Cascade Model of Autism Spectrum Disorder.International journal of molecular sciences · 2026
    Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

R E FryeArkansas Children's Hospital, Little Rock, AR, USA.
J SlatteryArkansas Children's Research Institute, Little Rock, AR, USA.
L DelheyArkansas Children's Research Institute, Little Rock, AR, USA.
B FurgersonArkansas Children's Hospital, Little Rock, AR, USA.
T StricklandArkansas Children's Hospital, Little Rock, AR, USA.
M TippettArkansas Children's Hospital, Little Rock, AR, USA.
A SaileyArkansas Children's Research Institute, Little Rock, AR, USA.
R WynneArkansas Children's Research Institute, Little Rock, AR, USA.
S RoseArkansas Children's Research Institute, Little Rock, AR, USA.
S MelnykArkansas Children's Research Institute, Little Rock, AR, USA.
S Jill JamesArkansas Children's Research Institute, Little Rock, AR, USA.
J M SequeiraDepartment of Medicine, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.
E V QuadrosDepartment of Medicine, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.
Arkansas Children's Hospital · USUniversity of Arkansas for Medical Sciences · USSUNY Downstate Health Sciences University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We sought to determine whether high-dose folinic acid improves verbal communication in children with non-syndromic autism spectrum disorder (ASD) and language impairment in a double-blind placebo control setting. Forty-eight children (mean age 7 years 4  months; 82% male) with ASD and language impairment were randomized to receive 12 weeks of high-dose folinic acid (2 mg kg

Indexed as

Autism Spectrum DisorderAutistic DisorderChildChild Development Disorders, PervasiveChild, PreschoolDouble-Blind MethodFemaleFolate Receptor 1HumansLanguage Development DisordersLanguage DisordersLeucovorinMalePlacebo EffectReceptors, PeptideTreatment OutcomeFolate Receptor 1glutathione receptorLeucovorinReceptors, Peptide

Identifiers

PMID27752075
PMCPMC5794882
OpenAlexW2536387587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.